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Details on Person UniProt:Q9NV88 INTS9

Class:Id	ReferenceGeneProduct:232909
_chainChangeLog	chain:1-658 added on Fri February 6 2015
_displayName	UniProt:Q9NV88 INTS9
_timestamp	2025-05-21 21:43:16
chain	chain:1-658
checksum	81F1A24B99704684
comment	FUNCTION Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:22252320, PubMed:26308897, PubMed:30737432). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267).SUBUNIT Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15 (PubMed:16239144, PubMed:25201415, PubMed:33243860, PubMed:33548203, PubMed:34762484, PubMed:38570683, PubMed:39032490). The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34762484, PubMed:36869814, PubMed:38570683). INTS9 is part of the RNA endonuclease subcomplex, composed of INTS4, INTS9, INTS11 and inositol hexakisphosphate (InsP6) (PubMed:29471365, PubMed:33548203). Interacts with WDR73; interaction is required for the assembly of the RNA endonuclease subcomplex in the cytoplasm (PubMed:33686175, PubMed:39032489). Interacts with BRAT1; interaction is required for the assembly of the RNA endonuclease subcomplex (PubMed:39032489, PubMed:39032490). Interacts with ESRRB, ESRRB is not a core component of the Integrator complex and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).INTERACTION Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.SIMILARITY Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: fullName evidence="24"Integrator complex subunit 9 shortName: Int9 alternativeName: fullName evidence="22"Protein related to CPSF subunits of 74 kDa shortName evidence="22"RC-74
geneName	INTS9 RC74
identifier	Q9NV88
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cytoplasm Isopeptide bond Nucleus Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
name	INTS9
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8999572] ENSEMBL:ENSG00000104299 INTS9 [Homo sapiens]
secondaryIdentifier	INT9_HUMAN B7Z560 B7Z6M5 O00224 Q8TB16
sequenceLength	658
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8968823] UniProt:Q9NV88-1 INTS9 [Homo sapiens] [ReferenceIsoform:8968824] UniProt:Q9NV88-2 INTS9 [Homo sapiens] [ReferenceIsoform:8968825] UniProt:Q9NV88-3 INTS9 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:6807424] INTS9 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9NV88 INTS9 (232909)