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Details on Person UniProt:Q8IZJ0 IFNL2
| Class:Id | ReferenceGeneProduct:232663 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;chain:26-200 added on Fri February 6 2015 |
| _displayName | UniProt:Q8IZJ0 IFNL2 |
| _timestamp | 2026-02-20 22:11:07 |
| chain | signal peptide:1-25 chain:26-200 |
| checksum | DFC7B49F31BF488E |
| comment | FUNCTION Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.SUBCELLULAR LOCATION By viral infections or double-stranded RNA.SIMILARITY Belongs to the type-III (or lambda) interferon family.CAUTION It is uncertain whether Met-1 or Met-5 is the initiator.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION Interleukin-28 entry |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Interferon lambda-2 shortName: IFN-lambda-2 alternativeName: Cytokine Zcyto20 alternativeName: Interleukin-28A shortName: IL-28A |
| geneName | IFNL2 IL28A ZCYTO20 |
| identifier | Q8IZJ0 |
| isSequenceChanged | FALSE |
| keyword | Antiviral defense Cytokine Disulfide bond Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | IFNL2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000094] ENSEMBL:ENSG00000183709 IFNL2 [Homo sapiens] |
| secondaryIdentifier | IFNL2_HUMAN Q45KQ8 Q6VN55 Q8IWL7 |
| sequenceLength | 200 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:448587] IFNL2 [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8IZJ0 IFNL2 (232663)
