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Details on Person UniProt:Q5VWK5 IL23R

Class:Id	ReferenceGeneProduct:232652
_chainChangeLog	signal peptide:1-23 added on Fri February 6 2015;chain:24-629 added on Fri February 6 2015
_displayName	UniProt:Q5VWK5 IL23R
_timestamp	2024-11-03 20:14:51
chain	signal peptide:1-23 chain:24-629
checksum	AC63C89E81AABF05
comment	FUNCTION Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.SUBUNIT Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.INTERACTION Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.PTM Phosphorylated in response to IL23.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.MISCELLANEOUS Produced by translation in an alternate frame of the cDNA encoding isoform 4.MISCELLANEOUS Produced by translation in an alternate frame of the cDNA encoding isoform 5.MISCELLANEOUS Produced by translation in an alternate frame of the cDNA encoding isoform 2.MISCELLANEOUS Produced by translation in an alternate frame of the cDNA encoding isoform 3.SIMILARITY Belongs to the type I cytokine receptor family. Type 2 subfamily.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Interleukin-23 receptor shortName: IL-23 receptor shortName: IL-23R
geneName	IL23R
identifier	Q5VWK5
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell membrane Glycoprotein Immunity Inflammatory response Innate immunity Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	IL23R
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8948445] ENSEMBL:ENSG00000162594 IL23R [Homo sapiens]
secondaryIdentifier	IL23R_HUMAN C9JGX4 Q4VGP1 Q4VGP2 Q4VGP3 Q4VGP4 Q4VGP5 Q4VGP6 Q5VWK7 Q8IW84 Q8NFQ9 Q96AS1
sequenceLength	629
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:232653] UniProt:Q5VWK5-2 IL23R [Homo sapiens] [ReferenceIsoform:232654] UniProt:Q5VWK5-3 IL23R [Homo sapiens] [ReferenceIsoform:232655] UniProt:Q5VWK5-4 IL23R [Homo sapiens] [ReferenceIsoform:232656] UniProt:Q5VWK5-5 IL23R [Homo sapiens] [ReferenceIsoform:232657] UniProt:Q5VWK5-6 IL23R [Homo sapiens] [ReferenceIsoform:232658] UniProt:Q5VWK5-7 IL23R [Homo sapiens] [ReferenceIsoform:407495] UniProt:Q5VWK5-1 IL23R [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:447156] IL23R [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8950616] p-Y-IL23R [plasma membrane] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:8950734] O4'-phospho-L-tyrosine at unknown position
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No pathways have been reviewed or authored by UniProt:Q5VWK5 IL23R (232652)