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Details on Person UniProt:Q6NZJ6 Eif4g1
| Class:Id | ReferenceGeneProduct:232523 |
|---|---|
| _chainChangeLog | chain:1-1600 added on Fri February 6 2015 |
| _displayName | UniProt:Q6NZJ6 Eif4g1 |
| _timestamp | 2024-08-09 19:02:07 |
| chain | chain:1-1600 |
| checksum | 8664A8B449C7A128 |
| comment | FUNCTION Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon. Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation.SUBUNIT eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3. Interacts with eIF3 complex, mutually exclusive with EIF4A1 or EIF4A2, EIF4E and through its N-terminus with PABPC1. Interacts with EIF4E or with EIF1 (mutually exclusive) through a common binding site. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity). Interacts with EIF4E3 (PubMed:15153109). Interacts with CIRBP and MIF4GD. Interacts with RBM4. Interacts with HNRNPD/AUF1; the interaction requires RNA. Interacts with DDX3X; the interaction requires RNA. Interacts with DAZAP2 (By similarity).SUBUNIT (Microbial infection) Interacts with murine norovirus viral genome-linked protein (via C-terminus); this interaction plays a role in translation of viral proteins.INTERACTION Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1187 by PRKCA induces binding to MKNK1.SIMILARITY Belongs to the eukaryotic initiation factor 4G family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Eukaryotic translation initiation factor 4 gamma 1 shortName: eIF-4-gamma 1 shortName: eIF-4G 1 shortName: eIF-4G1 |
| geneName | Eif4g1 |
| identifier | Q6NZJ6 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cytoplasm Initiation factor Methylation Nucleus Phosphoprotein Protein biosynthesis Reference proteome RNA-binding Translation regulation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618410] Weiser, JD [InstanceEdit:5618413] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Eif4g1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IF4G1_MOUSE Q6NZN8 Q8BW99 |
| sequenceLength | 1600 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:232524] UniProt:Q6NZJ6-2 Eif4g1 [Mus musculus] [ReferenceIsoform:408376] UniProt:Q6NZJ6-1 Eif4g1 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9817630] Eif4g1 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q6NZJ6 Eif4g1 (232523)
