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Query author contributions in Reactome
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Details on Person UniProt:Q8BGD9 Eif4b
Class:Id
ReferenceGeneProduct:232514
_chainChangeLog
chain:1-611 added on Fri February 6 2015
_displayName
UniProt:Q8BGD9 Eif4b
_timestamp
2023-11-03 18:00:33
chain
chain:1-611
checksum
A3254EBF55EDB6F2
comment
FUNCTION Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F (By similarity).SUBUNIT Self-associates and interacts with EIF3 p170 subunit.PTM Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex. In response to mTORC1 activation, RPS6KA1-mediated phosphorylation at 'Ser-406' and 'Ser-422' stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function.
