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Details on Person UniProt:Q60819 Il15ra
| Class:Id | ReferenceGeneProduct:232362 |
|---|---|
| _chainChangeLog | signal peptide:1-32 added on Fri February 6 2015;chain:33-263 added on Fri February 6 2015;chain:33- added on Fri February 6 2015 |
| _displayName | UniProt:Q60819 Il15ra |
| _timestamp | 2023-11-03 15:48:30 |
| chain | signal peptide:1-32 chain:33-263 chain:33- |
| checksum | BFCC2CE4BA58B504 |
| comment | FUNCTION High-affinity receptor for interleukin-15 (PubMed:17947230). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (PubMed:17947230). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (By similarity).SUBUNIT The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK (By similarity).SUBCELLULAR LOCATION Widely expressed.PTM N-glycosylated and O-glycosylated.PTM A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (By similarity). It also binds IL15 and thus interferes with IL15 binding to the membrane receptor (By similarity).CAUTION It was shown that proteolytic cleavage of Il15ra involves ADAM17/TACE; this publication has later been retracted. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Interleukin-15 receptor subunit alpha shortName: IL-15 receptor subunit alpha shortName: IL-15R-alpha shortName: IL-15RA cdAntigenNameCD215/cdAntigenName component recommendedName: Soluble interleukin-15 receptor subunit alpha shortName: sIL-15 receptor subunit alpha shortName: sIL-15R-alpha shortName: sIL-15RA /component |
| geneName | Il15ra |
| identifier | Q60819 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disulfide bond Glycoprotein Membrane Nucleus Phosphoprotein Receptor Reference proteome Secreted Signal Sushi Transmembrane Transmembrane helix |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Il15ra |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | I15RA_MOUSE A2AP35 A2AP36 A2AP37 Q80Z90 Q80Z91 Q80Z92 Q8R5E4 |
| sequenceLength | 263 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:232363] UniProt:Q60819-2 Il15ra [Mus musculus] [ReferenceIsoform:232364] UniProt:Q60819-3 Il15ra [Mus musculus] [ReferenceIsoform:232365] UniProt:Q60819-4 Il15ra [Mus musculus] [ReferenceIsoform:232366] UniProt:Q60819-5 Il15ra [Mus musculus] [ReferenceIsoform:232367] UniProt:Q60819-6 Il15ra [Mus musculus] [ReferenceIsoform:407588] UniProt:Q60819-1 Il15ra [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:8983181] Il15ra [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q60819 Il15ra (232362)
