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Details on Person UniProt:Q13261 IL15RA
| Class:Id | ReferenceGeneProduct:232353 |
|---|---|
| _chainChangeLog | signal peptide:1-30 added on Sat February 7 2015;chain:31-267 added on Sat February 7 2015;chain:31- added on Sat February 7 2015 |
| _displayName | UniProt:Q13261 IL15RA |
| _timestamp | 2024-11-03 19:41:20 |
| chain | signal peptide:1-30 chain:31-267 chain:31- |
| checksum | A9CFC885189E96BE |
| comment | FUNCTION High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910).FUNCTION Does not bind IL15.FUNCTION Does not bind IL15.FUNCTION Does not bind IL15.FUNCTION Does not bind IL15.SUBUNIT The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (PubMed:17643103). Interacts with SYK (PubMed:15123770).INTERACTION Mainly found associated with the nuclear membrane.SUBCELLULAR LOCATION Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.SUBCELLULAR LOCATION Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.SUBCELLULAR LOCATION Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.SUBCELLULAR LOCATION Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.SUBCELLULAR LOCATION Expressed in neutrophils (at protein level) (PubMed:15123770). Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus (PubMed:12114302). Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures (PubMed:12114302). Isoforms 1, 3, 4, 5, 6, 7, 8 and 9: Widely expressed (PubMed:10480910, PubMed:8530383).PTM N-glycosylated and O-glycosylated.PTM A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (PubMed:15265897). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor (PubMed:15265897).SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Interleukin-15 receptor subunit alpha shortName: IL-15 receptor subunit alpha shortName: IL-15R-alpha shortName: IL-15RA cdAntigenNameCD215/cdAntigenName component recommendedName: Soluble interleukin-15 receptor subunit alpha shortName: sIL-15 receptor subunit alpha shortName: sIL-15R-alpha shortName: sIL-15RA /component |
| geneName | IL15RA |
| identifier | Q13261 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasmic vesicle Disulfide bond Endoplasmic reticulum Glycoprotein Golgi apparatus Membrane Nucleus Phosphoprotein Proteomics identification Receptor Reference proteome Secreted Signal Sushi Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IL15RA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999564] ENSEMBL:ENSG00000134470 IL15RA [Homo sapiens] |
| secondaryIdentifier | I15RA_HUMAN B4E2C2 Q3B769 Q5JVA1 Q5JVA2 Q5JVA4 Q6B0J2 Q7LDR4 Q7Z609 |
| sequenceLength | 267 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:232355] UniProt:Q13261-3 IL15RA [Homo sapiens] [ReferenceIsoform:232356] UniProt:Q13261-4 IL15RA [Homo sapiens] [ReferenceIsoform:232357] UniProt:Q13261-5 IL15RA [Homo sapiens] [ReferenceIsoform:232358] UniProt:Q13261-6 IL15RA [Homo sapiens] [ReferenceIsoform:232359] UniProt:Q13261-7 IL15RA [Homo sapiens] [ReferenceIsoform:232360] UniProt:Q13261-8 IL15RA [Homo sapiens] [ReferenceIsoform:232361] UniProt:Q13261-9 IL15RA [Homo sapiens] [ReferenceIsoform:405581] UniProt:Q13261-1 IL15RA [Homo sapiens] [ReferenceIsoform:8976044] UniProt:Q13261-10 IL15RA [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:449122] IL15RA [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8983117] IL15RA [endosome] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q13261 IL15RA (232353)
