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Details on Person UniProt:Q9P2D3 HEATR5B
| Class:Id | ReferenceGeneProduct:232263 |
|---|---|
| _chainChangeLog | chain:1-2071 added on Fri February 6 2015 |
| _displayName | UniProt:Q9P2D3 HEATR5B |
| _timestamp | 2024-11-03 20:19:27 |
| chain | chain:1-2071 |
| checksum | 5CAAD3A49BFC975E |
| comment | FUNCTION Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025).SUBUNIT Self-associates (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, at least composed of AFTPH/aftiphilin, HEATR5B/p200a and SYNRG/gamma-synergin, which plays a role in the AP1G1/AP-1-mediated protein trafficking from early to recycling endosomes and between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). Within the complex interacts with AFTPH/aftiphilin and SYNRG/gamma-synergin; the interactions are direct (PubMed:15758025). Interacts with GGA1 (PubMed:15758025).INTERACTION Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin.ALTERNATIVE PRODUCTS Belongs to the HEATR5 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: HEAT repeat-containing protein 5B |
| geneName | HEATR5B KIAA1414 p200 p200a |
| identifier | Q9P2D3 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Cytoplasmic vesicle Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HEATR5B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961143] ENSEMBL:ENSG00000008869 HEATR5B [Homo sapiens] |
| secondaryIdentifier | HTR5B_HUMAN B5MDU8 Q7Z3B2 Q9NVL7 |
| sequenceLength | 2071 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:232264] UniProt:Q9P2D3-2 HEATR5B [Homo sapiens] [ReferenceIsoform:232265] UniProt:Q9P2D3-3 HEATR5B [Homo sapiens] [ReferenceIsoform:415033] UniProt:Q9P2D3-1 HEATR5B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8961300] HEATR5B [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9P2D3 HEATR5B (232263)
