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Details on Person UniProt:Q8WWQ2-4 HPSE2
| Class:Id | ReferenceIsoform:232161 |
|---|---|
| _chainChangeLog | signal peptide:1-41 added on Fri February 6 2015;chain:42-592 added on Fri February 6 2015 |
| _displayName | UniProt:Q8WWQ2-4 HPSE2 |
| _timestamp | 2025-05-21 21:12:20 |
| chain | signal peptide:1-41 chain:42-592 |
| checksum | 95C384AD9A6C868E |
| comment | FUNCTION Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).SUBUNIT Interacts with HPSE. Interacts with SDC1 (via glycan chains).SUBCELLULAR LOCATION Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal cord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.DEVELOPMENTAL STAGE Expressed in the developing forebrain, diencephalon, midbrain, hind brain and spinal cord at Carnagie stage 16 (CS16, 6 weeks of gestation) and CS21 (8 weeks).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the glycosyl hydrolase 79 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Inactive heparanase-2 shortName: Hpa2 |
| geneName | HPSE2 HPA2 |
| identifier | Q8WWQ2 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Extracellular matrix Glycoprotein Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | HPSE2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990171] ENSEMBL:ENSG00000172987 HPSE2 [Homo sapiens] |
| secondaryIdentifier | HPSE2_HUMAN Q5VUH4 Q5VUH5 Q5VUH6 Q8WWQ1 Q9HB37 Q9HB38 Q9HB39 |
| sequenceLength | 592 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8WWQ2-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8WWQ2-4 HPSE2 (232161)
