THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE.
WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE
Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8WWQ2 HPSE2
Class:Id
ReferenceGeneProduct:232158
_chainChangeLog
signal peptide:1-41 added on Fri February 6 2015;chain:42-592 added on Fri February 6 2015
_displayName
UniProt:Q8WWQ2 HPSE2
_timestamp
2025-05-21 21:12:20
chain
signal peptide:1-41 chain:42-592
checksum
95C384AD9A6C868E
comment
FUNCTION Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).SUBUNIT Interacts with HPSE. Interacts with SDC1 (via glycan chains).SUBCELLULAR LOCATION Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal cord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.DEVELOPMENTAL STAGE Expressed in the developing forebrain, diencephalon, midbrain, hind brain and spinal cord at Carnagie stage 16 (CS16, 6 weeks of gestation) and CS21 (8 weeks).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the glycosyl hydrolase 79 family.
