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Details on Person UniProt:Q9NQ87 HEYL
| Class:Id | ReferenceGeneProduct:231889 |
|---|---|
| _chainChangeLog | chain:1-328 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NQ87 HEYL |
| _timestamp | 2024-11-03 19:36:40 |
| chain | chain:1-328 |
| checksum | C11A1EAB18611F43 |
| comment | FUNCTION Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.SUBUNIT Self-associates. Interacts with GATA4, GATA6, HES1, HEY1 and HEY2. Interacts with HDAC1, NCOR1 and SIN3A.INTERACTION By activation of the Notch signaling pathway.SIMILARITY Belongs to the HEY family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Hairy/enhancer-of-split related with YRPW motif-like protein shortName: hHeyL alternativeName: Class B basic helix-loop-helix protein 33 shortName: bHLHb33 alternativeName: Hairy-related transcription factor 3 shortName: HRT-3 shortName: hHRT3 |
| geneName | HEYL BHLHB33 HRT3 |
| identifier | Q9NQ87 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein DNA-binding Notch signaling pathway Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HEYL |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:4396367] ENSEMBL:ENSG00000163909 HEYL [Homo sapiens] |
| secondaryIdentifier | HEYL_HUMAN Q5TG99 |
| sequenceLength | 328 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1606748] HEYL [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NQ87 HEYL (231889)
