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Details on Person SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum

Class:Id	Reaction:2317530
_displayName	SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum
_doRelease	TRUE
_timestamp	2026-04-13 17:35:18
authored	[InstanceEdit:2317525] May, B, 2012-06-10
catalystActivity	[CatalystActivity:9987239] protein sequestering activity of SREBP1A,1C,2:SCAP [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9987234] protein sequestering activity of SREBP1A,1C,2:SCAP [endoplasmic reticulum membrane] Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:2317527] May, B, 2012-06-13
edited	[InstanceEdit:2317525] May, B, 2012-06-10
goBiologicalProcess	[GO_BiologicalProcess:5263256] maintenance of protein complex location
inferredFrom	[BlackBoxEvent:2317526] SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG [Cricetulus griseus]
input	[Complex:2317520] SREBP1A,1C,2:SCAP [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:1655749] INSIG [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:1655749] INSIG [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:1655749] INSIG [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:1655749] INSIG [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:193384] CHOL [endoplasmic reticulum membrane] [SimpleEntity:193384] CHOL [endoplasmic reticulum membrane] [SimpleEntity:193384] CHOL [endoplasmic reticulum membrane] [SimpleEntity:193384] CHOL [endoplasmic reticulum membrane]
internalReviewed	[InstanceEdit:9987328] D'Eustachio, Peter, 2026-04-13
isChimeric	FALSE
modified	[InstanceEdit:2317539] May, B, 2012-06-13 [InstanceEdit:2326882] May, B, 2012-06-21 [InstanceEdit:2426596] May, B, 2012-08-08 [InstanceEdit:2426692] May, B, 2012-08-08 [InstanceEdit:2457633] May, B, 2012-08-25 [InstanceEdit:5260272] May, B, 2014-02-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9959903] D'Eustachio, Peter, 2025-07-02 [InstanceEdit:9987236] D'Eustachio, Peter, 2026-04-10 [InstanceEdit:9987329] D'Eustachio, Peter, 2026-04-13 [InstanceEdit:9987332] D'Eustachio, Peter, 2026-04-13
name	SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum SREBF1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum
output	[Complex:1655766] SREBP1A,1C,2:SCAP:cholesterol:INSIG [endoplasmic reticulum membrane] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-09-18
reviewed	[InstanceEdit:2457630] Liang, Guosheng, 2012-08-25 [InstanceEdit:9987331] Hill, David P, 2026-04-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2465024] R-HSA-2317530.3
structureModified	[InstanceEdit:9987236] D'Eustachio, Peter, 2026-04-10
summation	[Summation:2317537] SREBPs (SREBP1A/1C/2, SREBFs) bind SCAP in the endoplasmic r...
(hasEvent)	[Pathway:1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) [Homo sapiens]
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No pathways have been reviewed or authored by SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (2317530)