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Details on Person PTEN cancer mutants do not dephosphorylate PIP3

Class:IdFailedReaction:2317387
_displayNamePTEN cancer mutants do not dephosphorylate PIP3
_doReleaseTRUE
_timestamp2019-11-12 17:41:51
authored[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity[CatalystActivity:2317396] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN Mutants [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:2317389] Orlic-Milacic, M, 2012-06-11
disease[Disease:1500689] cancer
edited[InstanceEdit:2426555] Matthews, L, 2012-08-03
[InstanceEdit:9659463] Orlic-Milacic, Marija, 2019-08-27
entityFunctionalStatus[EntityFunctionalStatus:5674405] loss_of_function of PTEN Mutants [cytosol]
input[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
[SimpleEntity:29356] H2O [cytosol]
literatureReference[LiteratureReference:2318613] PTEN loss in the continuum of common cancers, rare syndromes and mouse models
[LiteratureReference:2317493] Crystal structure of human protein tyrosine phosphatase 1B
[LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
[LiteratureReference:1889775] Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay
[LiteratureReference:2317362] Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity
[LiteratureReference:2317361] PTEN1 is frequently mutated in primary endometrial carcinomas
[LiteratureReference:2317403] Molecular genetic defects in endometrial carcinomas: microsatellite instability, PTEN and beta-catenin (CTNNB1) genes mutations
[LiteratureReference:2318357] Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate
[LiteratureReference:2422409] Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
[LiteratureReference:9659466] The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
modified[InstanceEdit:2317492] Orlic-Milacic, M, 2012-06-12
[InstanceEdit:2318612] Orlic-Milacic, M, 2012-06-14
[InstanceEdit:2318712] Orlic-Milacic, M, 2012-06-15
[InstanceEdit:2404247] Orlic-Milacic, M, 2012-07-16
[InstanceEdit:2408381] Orlic-Milacic, M, 2012-07-16
[InstanceEdit:2409049] Orlic-Milacic, M, 2012-07-17
[InstanceEdit:2409053] Orlic-Milacic, M, 2012-07-17
[InstanceEdit:2422420] Orlic-Milacic, M, 2012-07-18
[InstanceEdit:2428913] Orlic-Milacic, M, 2012-08-08
[InstanceEdit:2457752] Orlic-Milacic, M, 2012-08-28
[InstanceEdit:2463861] Orlic-Milacic, M, 2012-08-30
[InstanceEdit:3080613] Orlic-Milacic, M, 2013-02-07
[InstanceEdit:5657601] Orlic-Milacic, Marija, 2014-12-15
[InstanceEdit:5674406] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:6793435] Orlic-Milacic, Marija, 2015-09-01
[InstanceEdit:9630060] Orlic-Milacic, Marija, 2018-11-28
[InstanceEdit:9659471] Orlic-Milacic, Marija, 2019-08-27
[InstanceEdit:9667510] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePTEN cancer mutants do not dephosphorylate PIP3
normalReaction
releaseDate2012-09-18
reviewed[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13
[InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
[InstanceEdit:9660647] D'Eustachio, Peter, 2019-09-11
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9659463] Orlic-Milacic, Marija, 2019-08-27
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2464888] R-HSA-2317387.5
summation[Summation:2318611] One of the functions of PTEN is to act as a phosphoinositide...
(hasEvent)[Pathway:3080611] Loss of PTEN Lipid Phosphatase Activity in Cancer [Homo sapiens]
[Pathway:5674404] PTEN Loss of Function in Cancer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777416] Update Tracker - [FailedReaction:2317387] PTEN cancer mutants do not dephosphorylate PIP3 - v71:[addLiteratureReference, modifyText]
[_UpdateTracker:9778613] Update Tracker - [FailedReaction:2317387] PTEN cancer mutants do not dephosphorylate PIP3 - v68:[addCatalystActivity]
[_UpdateTracker:9785498] Update Tracker - [FailedReaction:2317387] PTEN cancer mutants do not dephosphorylate PIP3 - v52:[removeCatalystActivity]
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