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Details on Person UniProt:Q75N03 CBLL1
| Class:Id | ReferenceGeneProduct:231508 |
|---|---|
| _chainChangeLog | chain:1-491 added on Sat February 7 2015 |
| _displayName | UniProt:Q75N03 CBLL1 |
| _timestamp | 2024-11-03 20:14:40 |
| chain | chain:1-491 |
| checksum | 1A733A8CC28F3AA0 |
| comment | FUNCTION E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Homodimer (By similarity). Interacts with tyrosine-phosphorylated SRC substrates (By similarity). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29507755). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29507755). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29507755). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).INTERACTION Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.ALTERNATIVE PRODUCTS The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.PTM Phosphorylated on tyrosine residues.SIMILARITY Belongs to the Hakai family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="8"E3 ubiquitin-protein ligase Hakai ecNumber evidence="1"2.3.2.27 alternativeName: fullName evidence="1"Casitas B-lineage lymphoma-transforming sequence-like protein 1 shortName evidence="1"c-Cbl-like protein 1 alternativeName: RING finger protein 188 alternativeName: fullName evidence="8"RING-type E3 ubiquitin transferase Hakai |
| geneName | CBLL1 HAKAI RNF188 |
| identifier | Q75N03 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Developmental protein Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CBLL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991304] ENSEMBL:ENSG00000105879 CBLL1 [Homo sapiens] |
| secondaryIdentifier | HAKAI_HUMAN B7ZM03 Q8TAJ4 Q9H5S6 |
| sequenceLength | 491 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966112] UniProt:Q75N03-1 CBLL1 [Homo sapiens] [ReferenceIsoform:8966113] UniProt:Q75N03-2 CBLL1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8855006] CBLL1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8876832] CBLL1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q75N03 CBLL1 (231508)
