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Details on Person ASA- acetylates PTGS1

Class:Id	Reaction:2314678
_displayName	ASA- acetylates PTGS1
_doRelease	TRUE
_timestamp	2021-10-21 08:51:20
authored	[InstanceEdit:2314689] D'Eustachio, P, 2012-06-07
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:2314688] D'Eustachio, P, 2012-06-07
edited	[InstanceEdit:2314689] D'Eustachio, P, 2012-06-07
input	[Complex:428986] PTGS1 dimer [endoplasmic reticulum membrane] [Homo sapiens] [ChemicalDrug:2314693] ASA- [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2314696] Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin [LiteratureReference:2316257] The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase
modified	[InstanceEdit:2314697] D'Eustachio, P, 2012-06-07 [InstanceEdit:2316259] D'Eustachio, P, 2012-06-07 [InstanceEdit:2569041] D'Eustachio, P, 2012-11-10 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9677519] Jassal, Bijay, 2020-03-05 [InstanceEdit:9677627] Jassal, Bijay, 2020-03-09 [InstanceEdit:9756906] Shamovsky, Veronica, 2021-10-21 [InstanceEdit:9756909] Shamovsky, Veronica, 2021-10-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ASA- acetylates PTGS1
output	[Complex:2314695] Ac-PTGS1 dimer [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:2314690] ST [cytosol]
precedingEvent	[Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9757434] Acetylsalicylic acid dissolves [Homo sapiens] [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT [Homo sapiens] [Reaction:9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells [Homo sapiens] [Reaction:9757434] Acetylsalicylic acid dissolves [Homo sapiens] [Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens] [BlackBoxEvent:9757441] ASA- (GI) translocates from cytosol to extracellular region [Homo sapiens] [BlackBoxEvent:9757448] ST translocates from cytosol to extracellular region [Homo sapiens] [Reaction:9749609] BCHE hydrolyzes ASA- [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200486] R-HSA-2314678.5
summation	[Summation:2314691] The ionized form of aspirin, acetylsalicylate (ASA-) reacts ...
(hasEvent)	[Pathway:2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775395] Update Tracker - [Reaction:2314678] ASA- acetylates PTGS1 - v79:[modifyText] [_UpdateTracker:9919364] Update Tracker - [Reaction:2314678] ASA- acetylates PTGS1 - v90:[modifyText]
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