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Details on Person UniProt:O35793 Grem1
| Class:Id | ReferenceGeneProduct:231123 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 6 2015;chain:25-184 added on Fri February 6 2015 |
| _displayName | UniProt:O35793 Grem1 |
| _timestamp | 2023-11-03 15:27:43 |
| chain | signal peptide:1-24 chain:25-184 |
| checksum | 90AC99749B1AD8F6 |
| comment | FUNCTION Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (PubMed:15528323). Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.SUBUNIT Homodimer; can also form homooligomers. Interacts with BMP2; can form higher oligomers with BMP2 (By similarity). Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner (PubMed:15528323).SUBCELLULAR LOCATION Highly expressed in the brain, kidney, spleen, and testis and weakly expressed in the lung and liver. Predominantly expressed in differentiated cells as neurons in brain, type I cells in lung and globlet cells in intestine.INDUCTION Down-regulated in cells transformed by oncogenes.SIMILARITY Belongs to the DAN family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Gremlin-1 alternativeName: Cysteine knot superfamily 1, BMP antagonist 1 alternativeName: Down-regulated in Mos-transformed cells protein |
| geneName | Grem1 Cktsf1b1 Drm |
| identifier | O35793 |
| isSequenceChanged | FALSE |
| keyword | Cytokine Disulfide bond Glycoprotein Reference proteome Secreted Signal |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Grem1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GREM1_RAT |
| sequenceLength | 184 |
| species | [Species:48895] Rattus norvegicus |
| (referenceEntity) | [EntityWithAccessionedSequence:9831903] Grem1 [extracellular region] [Rattus norvegicus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O35793 Grem1 (231123)
