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Details on Person UniProt:Q9Y2T6 GPR55
| Class:Id | ReferenceGeneProduct:231010 |
|---|---|
| _chainChangeLog | chain:1-319 added on Sat February 7 2015 |
| _displayName | UniProt:Q9Y2T6 GPR55 |
| _timestamp | 2026-02-20 23:05:58 |
| chain | chain:1-319 |
| checksum | D6E5C6CA8426E7D5 |
| comment | FUNCTION G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935).SUBCELLULAR LOCATION Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts. Highly expressed in macrophages and B-cells (PubMed:36523570, PubMed:37544935).MISCELLANEOUS The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: G-protein coupled receptor 55 |
| geneName | GPR55 |
| identifier | Q9Y2T6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GPR55 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996601] ENSEMBL:ENSG00000135898 GPR55 [Homo sapiens] |
| secondaryIdentifier | GPR55_HUMAN Q8N580 |
| sequenceLength | 319 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:444504] GPR55 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y2T6 GPR55 (231010)
