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Details on Person PGG2 is reduced to PGH2 by PTGS2

Class:Id	Reaction:2309773
_displayName	PGG2 is reduced to PGH2 by PTGS2
_doRelease	TRUE
_timestamp	2024-08-02 18:54:58
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:2309777] peroxidase activity of PTGS2 dimer [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9915543] peroxidase activity of PTGS2 dimer [endoplasmic reticulum membrane] Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:2309789] D'Eustachio, P, 2012-06-05
crossReference	[DatabaseIdentifier:9915541] RHEA:42600
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
input	[SimpleEntity:140357] PGG2 [endoplasmic reticulum lumen] [SimpleEntity:9915557] hydrogen donor [endoplasmic reticulum lumen]
internalReviewed	[InstanceEdit:9915780] D'Eustachio, Peter, 2024-07-15
literatureReference	[LiteratureReference:140567] Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis [LiteratureReference:2162129] Human cyclooxygenase-2 cDNA [LiteratureReference:2162103] Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid [LiteratureReference:2162150] Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
modified	[InstanceEdit:2309791] D'Eustachio, P, 2012-06-05 [InstanceEdit:2569041] D'Eustachio, P, 2012-11-10 [InstanceEdit:8940088] Jassal, Bijay, 2016-09-23 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9677535] Jassal, Bijay, 2020-03-06 [InstanceEdit:9696626] Jassal, Bijay, 2020-07-23 [InstanceEdit:9735228] Jassal, Bijay, 2021-06-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915565] D'Eustachio, Peter, 2024-07-11 [InstanceEdit:9915779] D'Eustachio, Peter, 2024-07-15 [InstanceEdit:9917368] D'Eustachio, Peter, 2024-08-02
name	PGG2 is reduced to PGH2 by PTGS2 AH2 + prostaglandin G2 = A + H2O + prostaglandin H2 Peroxidative reduction of PGG2 to PGH2
output	[SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:30138] PGH2 [endoplasmic reticulum lumen] [SimpleEntity:9915551] hydrogen acceptor [endoplasmic reticulum lumen]
precedingEvent	[Reaction:2309787] Arachidonate is oxidised to PGG2 by PTGS2 [Homo sapiens] [Reaction:111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:5362144] Positive regulation by 'MNA [cytosol]' [NegativeRegulation:9677534] Negative regulation by 'PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane]'
regulationReference	[RegulationReference:9735229] Negative regulation by 'PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane]' Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2
releaseDate	2008-06-30
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464943] R-HSA-2309773.8
structureModified	[InstanceEdit:9915565] D'Eustachio, Peter, 2024-07-11
summation	[Summation:2309784] Prostaglandin G/H synthase 2 (PTGS2) exhibits a dual catalyt...
(hasEvent)	[Pathway:2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) [Homo sapiens]
(precedingEvent)	[Reaction:76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 [Homo sapiens] [Reaction:76500] TBXAS1 isomerises PGH2 to TXA2 [Homo sapiens] [Reaction:2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1 [Homo sapiens] [Reaction:2161620] PGH2 is isomerised to PGD2 by PTGDS [Homo sapiens] [BlackBoxEvent:2299725] PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776981] Update Tracker - [Reaction:2309773] PGG2 is reduced to PGH2 by PTGS2 - v73:[addRegulator] [_UpdateTracker:9786676] Update Tracker - [Reaction:2309773] PGG2 is reduced to PGH2 by PTGS2 - v49:[addRegulator] [_UpdateTracker:9919359] Update Tracker - [Reaction:2309773] PGG2 is reduced to PGH2 by PTGS2 - v90:[add_removeInput, removeOutput]
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