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Details on Person UniProt:Q5T6X5 GPRC6A

Class:Id	ReferenceGeneProduct:230968
_chainChangeLog	signal peptide:1-18 added on Fri February 6 2015;chain:19-926 added on Fri February 6 2015
_displayName	UniProt:Q5T6X5 GPRC6A
_timestamp	2026-02-20 22:21:53
chain	signal peptide:1-18 chain:19-926
checksum	2019C884FF092EEF
comment	FUNCTION Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (PubMed:15576628). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (By similarity). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (By similarity). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity). Mediates the non-genomic effects of androgens in multiple tissue (By similarity). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:20947496).SUBUNIT Homodimer; disulfide-linked.SUBCELLULAR LOCATION Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.MISCELLANEOUS Major isoform.SIMILARITY Belongs to the G-protein coupled receptor 3 family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: G-protein coupled receptor family C group 6 member A shortName: hGPRC6A alternativeName: G-protein coupled receptor GPCR33 shortName: hGPCR33
geneName	GPRC6A
identifier	Q5T6X5
isSequenceChanged	FALSE
keyword	Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	GPRC6A
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8995998] ENSEMBL:ENSG00000173612 GPRC6A [Homo sapiens]
secondaryIdentifier	GPC6A_HUMAN Q6JK43 Q6JK44 Q8NGU8 Q8NHZ9 Q8TDT6
sequenceLength	926
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:230969] UniProt:Q5T6X5-2 GPRC6A [Homo sapiens] [ReferenceIsoform:230970] UniProt:Q5T6X5-3 GPRC6A [Homo sapiens] [ReferenceIsoform:407372] UniProt:Q5T6X5-1 GPRC6A [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:420726] GPRC6A [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q5T6X5 GPRC6A (230968)