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Details on Person UniProt:Q8N158 GPC2

Class:Id	ReferenceGeneProduct:230962
_chainChangeLog	signal peptide:1-23 added on Fri February 6 2015;chain:24-554 added on Fri February 6 2015;chain:24- added on Fri February 6 2015;propeptide:555-579 added on Fri February 6 2015
_displayName	UniProt:Q8N158 GPC2
_timestamp	2024-11-03 19:41:07
chain	signal peptide:1-23 chain:24-554 chain:24- propeptide:555-579
checksum	1630E3A22BB83DFA
comment	FUNCTION Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).SUBUNIT Interacts (via heparan sulfate) with PTN; this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2. Interacts (heparan sulfate chain) with MDK; this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (By similarity).SUBCELLULAR LOCATION Belongs to the glypican family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Glypican-2 component recommendedName: Secreted glypican-2 /component
geneName	GPC2
identifier	Q8N158
isSequenceChanged	FALSE
keyword	3D-structure Cell membrane Glycoprotein GPI-anchor Heparan sulfate Lipoprotein Membrane Proteoglycan Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	GPC2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8990153] ENSEMBL:ENSG00000213420 GPC2 [Homo sapiens]
secondaryIdentifier	GPC2_HUMAN A4D2A7
sequenceLength	579
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:2054112] GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064006] Gal-Gal-Xyl-GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064009] Gal-Xyl-GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064059] GlcA-Gal-Gal-Xyl-GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2064221] XylS-GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076289] HS(3)-GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076293] Heparan-GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076316] Heparan(4)-GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076325] HS(1)-GPC2 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:2076354] HS(2)-GPC2 [Golgi lumen] [Homo sapiens] List all 26 refering instances
(referenceSequence)	[GroupModifiedResidue:2063958] O-xylosyl-L-serine (O3-(4-β-D-galactosyl-β-D-xylosyl)-L-serine residue) at unknown position [ModifiedResidue:2064014] O-xylosyl-L-serine at unknown position [GroupModifiedResidue:2064034] O-xylosyl-L-serine (3-O-(β-D-glucuronosyl-(1→3)-β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2064089] O-xylosyl-L-serine (O3-(β-D-galactosyl-(1→3)-β-D-galactosyl-(1→4)-β-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:2076292] O-xylosyl-L-serine (ChEBI:63648) at unknown position [GroupModifiedResidue:2076355] O-xylosyl-L-serine (ChEBI:63646) at unknown position [GroupModifiedResidue:2076428] O-xylosyl-L-serine (ChEBI:63666) at unknown position [GroupModifiedResidue:2076489] O-xylosyl-L-serine (ChEBI:63652) at unknown position [GroupModifiedResidue:2076496] O-xylosyl-L-serine (ChEBI:63657) at unknown position [GroupModifiedResidue:2076499] O-xylosyl-L-serine (ChEBI:63645) at unknown position List all 16 refering instances
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No pathways have been reviewed or authored by UniProt:Q8N158 GPC2 (230962)