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Details on Person UniProt:Q9NZC3 GDE1
| Class:Id | ReferenceGeneProduct:230355 |
|---|---|
| _chainChangeLog | chain:1-331 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NZC3 GDE1 |
| _timestamp | 2025-02-21 18:47:04 |
| chain | chain:1-331 |
| checksum | EFE567E71DBD4AC5 |
| comment | FUNCTION Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity).CATALYTIC ACTIVITY sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)CATALYTIC ACTIVITY 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H(+)CATALYTIC ACTIVITY 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-(9Z-octadecenoyl) ethanolamine + H(+)CATALYTIC ACTIVITY 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)CATALYTIC ACTIVITY N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine + H2O = N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate + H(+)CATALYTIC ACTIVITY N-eicosanoyl-sn-glycero-3-phosphoethanolamine + H2O = N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate + H(+)CATALYTIC ACTIVITY N-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + sn-glycerol 3-phosphate + H(+)CATALYTIC ACTIVITY N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate + H(+)CATALYTIC ACTIVITY N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate + H(+)COFACTOR Inhibited by EDTA, calcium chloride, and zinc chloride. Enhanced by magnesium chloride (By similarity). Glycerophosphodiester phosphodiesterase activity can be modulated by G-protein signaling pathways (By similarity).SUBUNIT Interacts with PRAF2 (PubMed:16472945). Interacts with RGS16 (By similarity).INTERACTION Perinuclear vesicles and cell membrane.TISSUE SPECIFICITY Widely expressed.PTM N-glycosylated.SIMILARITY Belongs to the glycerophosphoryl diester phosphodiesterase family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="7"Glycerophosphodiester phosphodiesterase 1 alternativeName: fullName evidence="7"Glycerophosphoinositol glycerophosphodiesterase GDE1 ecNumber evidence="1"3.1.4.44 alternativeName: fullName evidence="7"Lysophospholipase D GDE1 ecNumber evidence="2"3.1.4.- alternativeName: fullName evidence="6"Membrane-interacting protein of RGS16 alternativeName: RGS16-interacting membrane protein |
| geneName | GDE1 MIR16 |
| identifier | Q9NZC3 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Cytoplasmic vesicle Glycoprotein Hydrolase Lipid metabolism Magnesium Membrane Metal-binding Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | GDE1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990715] ENSEMBL:ENSG00000006007 GDE1 [Homo sapiens] |
| secondaryIdentifier | GDE1_HUMAN O43334 Q6PKF7 Q7KYR4 |
| sequenceLength | 331 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1498746] GDE1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NZC3 GDE1 (230355)
