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Details on Person UniProt:O95395 GCNT3
| Class:Id | ReferenceGeneProduct:230322 |
|---|---|
| _chainChangeLog | chain:1-438 added on Fri February 6 2015 |
| _displayName | UniProt:O95395 GCNT3 |
| _timestamp | 2026-02-20 21:59:27 |
| chain | chain:1-438 |
| checksum | 1FF0A7B451C88407 |
| comment | FUNCTION Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.CATALYTIC ACTIVITY a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP + H(+)CATALYTIC ACTIVITY a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = a 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP + H(+)CATALYTIC ACTIVITY a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-GlcNAc derivative + UDP + H(+)CATALYTIC ACTIVITY 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)CATALYTIC ACTIVITY a 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)PATHWAY Protein modification; protein glycosylation.SUBCELLULAR LOCATION Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.INDUCTION By all-trans retinoic acid (ATRA), TNF and IL13/interleukin-13. Strongly down-regulated in colorectal cancer.PTM N-glycosylated.SIMILARITY Belongs to the glycosyltransferase 14 family.ONLINE INFORMATION Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 ecNumber evidence="6"2.4.1.102 ecNumber evidence="6"2.4.1.148 ecNumber evidence="6"2.4.1.150 alternativeName: C2GnT-mucin type shortName: C2GnT-M shortName: hC2GnT-M alternativeName: Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase shortName: C2/4GnT |
| geneName | GCNT3 |
| identifier | O95395 |
| isSequenceChanged | FALSE |
| keyword | Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Membrane Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GCNT3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003543] ENSEMBL:ENSG00000140297 GCNT3 [Homo sapiens] |
| secondaryIdentifier | GCNT3_HUMAN |
| sequenceLength | 438 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:914013] GCNT3 [Golgi membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O95395 GCNT3 (230322)
