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Details on Person UniProt:Q8TAE8 GADD45GIP1
| Class:Id | ReferenceGeneProduct:230110 |
|---|---|
| _chainChangeLog | chain:1-222 added on Fri February 6 2015 |
| _displayName | UniProt:Q8TAE8 GADD45GIP1 |
| _timestamp | 2025-05-21 21:11:54 |
| chain | chain:1-222 |
| checksum | 304C397AEC958804 |
| comment | FUNCTION Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.SUBUNIT Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25278503, PubMed:25838379). Interacts with GADD45A, GADD45B and GADD45G (PubMed:12716909). Interacts with NR4A1 via the NR4A1 AB domain (PubMed:15459248). Interacts with ATAD3A and ATAD3B (PubMed:22453275).SUBUNIT (Microbial infection) Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2.INTERACTION Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275).TISSUE SPECIFICITY Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.INDUCTION Down-regulated by p53/TP53 in apoptotic cells.MISCELLANEOUS Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.SIMILARITY Belongs to the mitochondrion-specific ribosomal protein mL64 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="13"Large ribosomal subunit protein mL64 alternativeName: 39S ribosomal protein L59, mitochondrial shortName: MRP-L59 alternativeName: CKII beta-associating protein alternativeName: CR6-interacting factor 1 shortName: CRIF1 alternativeName: Growth arrest and DNA damage-inducible proteins-interacting protein 1 alternativeName: Papillomavirus L2-interacting nuclear protein 1 shortName: PLINP shortName: PLINP-1 alternativeName: p53-responsive gene 6 protein |
| geneName | GADD45GIP1 MRPL59 PLINP1 PRG6 |
| identifier | Q8TAE8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell cycle Coiled coil Host-virus interaction Mitochondrion Nucleus Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | GADD45GIP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003538] ENSEMBL:ENSG00000179271 GADD45GIP1 [Homo sapiens] |
| secondaryIdentifier | G45IP_HUMAN Q8IVM3 Q8TE51 Q969P9 Q9BSM6 |
| sequenceLength | 222 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5368253] GADD45GIP1 [mitochondrial matrix] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8TAE8 GADD45GIP1 (230110)
