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Details on Person UniProt:Q8C180 Frs2
| Class:Id | ReferenceGeneProduct:229927 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-508 added on Fri February 6 2015;initiator methionine:1 for 229927 removed on Fri Nov 03 2023;initiator methionine: for 229927 added on Fri Nov 03 2023;initiator methionine: for 229927 removed on Fri Aug 15 2025;initiator methionine:1 for 229927 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q8C180 Frs2 |
| _timestamp | 2025-08-15 21:22:39 |
| chain | initiator methionine:1 chain:2-508 |
| checksum | DFFE8A818BFF8631 |
| comment | FUNCTION Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.SUBUNIT Part of a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Part of a complex containing GRB2 and CBL. Binds ALK, CKS2, FGFR1, RET, MAPK1/ERK2, MAPK3/ERK1 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated upon ligand-binding) (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN.INTERACTION Ubiquitous. Expression is highest in brain, kidney, lung and testis.PTM Phosphorylated on tyrosine residues upon stimulation by FGF2 or NGFB. Phosphorylated by ULK2 (in vitro). Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.PTM Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Fibroblast growth factor receptor substrate 2 shortName: FGFR substrate 2 alternativeName: FGFR-signaling adaptor SNT alternativeName: FRS2-alpha alternativeName: Suc1-associated neurotrophic factor target 1 shortName: SNT-1 |
| geneName | Frs2 Frs2a |
| identifier | Q8C180 |
| isSequenceChanged | FALSE |
| keyword | Direct protein sequencing Lipoprotein Membrane Myristate Phosphoprotein Reference proteome Ubl conjugation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Frs2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FRS2_MOUSE |
| sequenceLength | 508 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:443125] Frs2 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:443227] Phospho FRS2 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:9031970] p-Y-Frs2 [cytosol] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:443119] O4'-phospho-L-tyrosine at 195 [ModifiedResidue:443129] O4'-phospho-L-tyrosine at 391 [ModifiedResidue:443298] O4'-phospho-L-tyrosine at 348 [ModifiedResidue:443327] O4'-phospho-L-tyrosine at 305 [ModifiedResidue:443344] O4'-phospho-L-tyrosine at 435 [ModifiedResidue:9031974] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q8C180 Frs2 (229927)
