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Details on Person UniProt:Q6UN15 FIP1L1

Class:IdReferenceGeneProduct:229638
_chainChangeLogchain:1-594 added on Fri February 6 2015
_displayNameUniProt:Q6UN15 FIP1L1
_timestamp2024-11-03 20:19:08
chainchain:1-594
checksumB391D142419ED061
commentFUNCTION Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.SUBUNIT Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with CPSF1, CPSF4, CSTF2 and CSTF3 (PubMed:14749727). Interacts with AHCYL1 (when phosphorylated); the interaction is direct and associates AHCYL1 with the CPSF complex and RNA (PubMed:19224921). Interacts with NUDT21/CPSF5; this interaction occurs in a RNA sequence-specific manner (PubMed:15937220). Interacts (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain) with CPSF6 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation (PubMed:29276085). Interacts (preferentially via unphosphorylated form and Arg/Asp/Glu-rich domain) with CPSF7 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation (PubMed:29276085). Interacts with PAPOLA; the interaction seems to be increased by the interaction with AHCYL1 (By similarity).INTERACTION A chromosomal aberration involving FIP1L1 is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).SIMILARITY Belongs to the FIP1 family.SEQUENCE CAUTION Intron retention.SEQUENCE CAUTION Intron retention.
created[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
descriptionrecommendedName: Pre-mRNA 3'-end-processing factor FIP1 shortName: hFip1 alternativeName: FIP1-like 1 protein alternativeName: Factor interacting with PAP alternativeName: Rearranged in hypereosinophilia
geneNameFIP1L1
FIP1
RHE
identifierQ6UN15
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
mRNA processing
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
RNA-binding
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameFIP1L1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8994807] ENSEMBL:ENSG00000145216 FIP1L1 [Homo sapiens]
secondaryIdentifierFIP1_HUMAN
B4DIR3
G3XAD6
Q0VGE0
Q499Y4
Q49AU3
Q7Z608
Q8WVN3
Q96F80
Q9H077
sequenceLength594
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:229640] UniProt:Q6UN15-3 FIP1L1 [Homo sapiens]
[ReferenceIsoform:229641] UniProt:Q6UN15-4 FIP1L1 [Homo sapiens]
[ReferenceIsoform:408688] UniProt:Q6UN15-1 FIP1L1 [Homo sapiens]
[ReferenceIsoform:8971432] UniProt:Q6UN15-5 FIP1L1 [Homo sapiens]
(referenceEntity)[EntityWithAccessionedSequence:6805150] FIP1L1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9672496] FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9672499] FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9672502] FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9672506] FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9673621] p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9673867] p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9673872] p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9673879] p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] [Homo sapiens]
(referenceSequence)[FragmentReplacedModification:9672470] Replacement of residues 391 to 391 by PAQCP
[FragmentReplacedModification:9672471] Replacement of residues 392 to 392 by GDCY
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No pathways have been reviewed or authored by UniProt:Q6UN15 FIP1L1 (229638)
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