Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Mitotic Prometaphase

Class:IdPathwayDiagram:2294586
_displayNameDiagram of Mitotic Prometaphase
_timestamp2024-03-05 00:54:00
created[InstanceEdit:2294582] Orlic-Milacic, M, 2012-05-31
height930
modified[InstanceEdit:2465954] Orlic-Milacic, M, 2012-09-04
[InstanceEdit:2466024] Orlic-Milacic, M, 2012-09-05
[InstanceEdit:2466067] Orlic-Milacic, M, 2012-09-05
[InstanceEdit:2466072] Orlic-Milacic, M, 2012-09-05
[InstanceEdit:2467815] Orlic-Milacic, M, 2012-09-13
[InstanceEdit:2468280] Orlic-Milacic, M, 2012-09-14
[InstanceEdit:2468296] Orlic-Milacic, M, 2012-09-14
[InstanceEdit:2468297] Orlic-Milacic, M, 2012-09-14
[InstanceEdit:2474794] Orlic-Milacic, M, 2012-09-24
[InstanceEdit:2484835] Orlic-Milacic, M, 2012-09-25
[InstanceEdit:2484911] Orlic-Milacic, M, 2012-09-26
[InstanceEdit:2485165] Orlic-Milacic, M, 2012-09-28
[InstanceEdit:2500238] Orlic-Milacic, M, 2012-10-01
[InstanceEdit:2500254] Orlic-Milacic, M, 2012-10-01
[InstanceEdit:2500292] Orlic-Milacic, M, 2012-10-01
[InstanceEdit:2505659] Orlic-Milacic, M, 2012-10-02
[InstanceEdit:2520886] Orlic-Milacic, M, 2012-10-11
[InstanceEdit:2520898] Orlic-Milacic, M, 2012-10-11
[InstanceEdit:2525922] Orlic-Milacic, M, 2012-10-12
[InstanceEdit:2529019] Orlic-Milacic, M, 2012-10-16
[InstanceEdit:2529023] Orlic-Milacic, M, 2012-10-16
[InstanceEdit:2531398] Orlic-Milacic, M, 2012-10-18
[InstanceEdit:2545189] Orlic-Milacic, M, 2012-10-31
[InstanceEdit:2545254] Orlic-Milacic, M, 2012-11-01
[InstanceEdit:2545255] Orlic-Milacic, M, 2012-11-01
[InstanceEdit:2550394] Orlic-Milacic, M, 2012-11-01
[InstanceEdit:2574850] Orlic-Milacic, M, 2012-11-12
[InstanceEdit:2577096] Orlic-Milacic, M, 2012-11-12
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8982286] Orlic-Milacic, Marija, 2017-03-16
[InstanceEdit:8982288] Orlic-Milacic, Marija, 2017-03-16
[InstanceEdit:8982289] Orlic-Milacic, Marija, 2017-03-16
[InstanceEdit:8982290] Orlic-Milacic, Marija, 2017-03-16
[InstanceEdit:8982341] Orlic-Milacic, Marija, 2017-03-17
[InstanceEdit:8982425] Orlic-Milacic, Marija, 2017-03-17
[InstanceEdit:9648029] Orlic-Milacic, Marija, 2019-06-04
[InstanceEdit:9648085] Orlic-Milacic, Marija, 2019-06-04
[InstanceEdit:9648112] Orlic-Milacic, Marija, 2019-06-04
[InstanceEdit:9648122] Orlic-Milacic, Marija, 2019-06-04
[InstanceEdit:9648123] Orlic-Milacic, Marija, 2019-06-04
[InstanceEdit:9648129] Orlic-Milacic, Marija, 2019-06-04
[InstanceEdit:9654818] Orlic-Milacic, Marija, 2019-07-22
[InstanceEdit:9658306] Orlic-Milacic, Marija, 2019-08-12
[InstanceEdit:9658314] Orlic-Milacic, Marija, 2019-08-12
[InstanceEdit:9663540] Orlic-Milacic, Marija, 2019-10-03
[InstanceEdit:9762838] Orlic-Milacic, Marija, 2022-01-28
[InstanceEdit:9851978] Orlic-Milacic, Marija, 2023-11-02
[InstanceEdit:9853442] Orlic-Milacic, Marija, 2023-11-15
[InstanceEdit:9853449] Orlic-Milacic, Marija, 2023-11-15
[InstanceEdit:9853468] Orlic-Milacic, Marija, 2023-11-15
[InstanceEdit:9863562] Orlic-Milacic, Marija, 2024-03-01
[InstanceEdit:9863719] Matthews, Lisa, 2024-03-05
representedPathway[Pathway:68877] Mitotic Prometaphase [Homo sapiens]
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textPosition="1772 291"> <Properties> <displayName>NUDC</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="4137" reactomeId="156702" position="1516 310" bounds="1451 298 130 25" textPosition="1452 299"> <Properties> <displayName>p-S274,S326-NUDC</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.07692307692307693" relativeY="0.0" label="P" trackId="0" reactomeId="156726" /> <org.gk.render.RenderableFeature relativeX="0.24615384615384617" relativeY="0.0" label="P" trackId="0" reactomeId="156689" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="4138" reactomeId="29370" position="1592 366" bounds="1570 354 45 25" textPosition="1576 355" /> <org.gk.render.RenderableProtein id="4139" reactomeId="3000318" position="1679 439" bounds="1631 428 97 22" textPosition="1634 428"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="1.0" relativeY="0.3365631342585864" label="P" trackId="0" reactomeId="3000316" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="4178" reactomeId="9648124" position="1345 448" bounds="1277 416 136 65" textPosition="1279 417" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore</displayName> </Properties> <OldBounds> <Bounds id="4178" bounds="1284 424 135 134" /> </OldBounds> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4179" reactomeId="2984255" position="1551 124" bounds="1495 99 112 50" textPosition="1499 99" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="4183" reactomeId="3000318" position="612 573" bounds="564 562 97 22" textPosition="567 562"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16494845360824742" relativeY="0.0" label="P" trackId="0" reactomeId="3000316" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="4189" reactomeId="9851948" position="1153 599" bounds="1130 588 46 23" textPosition="1131 588"> <Properties> <displayName>FIRRM</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="4190" reactomeId="9851951" position="1349 595" bounds="1283 579 132 32" textPosition="1284 589" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FIRRM:p-T210-PLK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="4192" reactomeId="113592" position="1420 634" bounds="1401 624 39 21" textPosition="1405 624" /> <org.gk.render.RenderableComplex id="4193" reactomeId="9851996" position="1586 592" bounds="1540 574 93 37" textPosition="1541 575" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S43-FIRRM:p-T210-PLK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="4194" reactomeId="29370" position="1521 647" bounds="1502 635 39 24" textPosition="1505 636" /> <org.gk.render.RenderableProtein id="4196" reactomeId="3000318" position="1181 538" bounds="1133 527 97 22" textPosition="1136 527"> <Properties> <displayName>p-T210-PLK1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16494845360824742" relativeY="0.0" label="P" trackId="0" reactomeId="3000316" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="4206" reactomeId="163443" position="1134 682" bounds="1108 671 52 23" textPosition="1111 665"> <Properties> <displayName>PPP1CC</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="4207" reactomeId="9853439" position="1302 699" bounds="1255 688 94 23" textPosition="1256 689" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FIRRM:PPP1CC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="4217" reactomeId="29356" position="1075 754" bounds="1056 744 39 21" textPosition="1058 744"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="4218" reactomeId="164603" position="1267 739" bounds="1249 728 37 23" textPosition="1249 728"> <Properties> <displayName>PLK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="4220" reactomeId="29372" position="1278 770" bounds="1262 759 32 23" textPosition="1269 759" /> <org.gk.render.RenderableChemical id="4242" reactomeId="113592" position="1630 666" bounds="1610 655 40 22" textPosition="1614 655" /> <org.gk.render.RenderableProtein id="4243" reactomeId="9853437" position="1451 757" bounds="1389 742 124 31" textPosition="1390 746"> <Properties> <displayName>p-S43,S744-FIRRM</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.12903225806451613" relativeY="0.0" label="P" trackId="0" reactomeId="9851991" /> <org.gk.render.RenderableFeature relativeX="0.25806451612903225" relativeY="0.0" label="P" trackId="0" reactomeId="9853434" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="4250" reactomeId="29370" position="1668 722" bounds="1646 710 45 24" textPosition="1652 711" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="618" reactomeId="1638803" points="744 538, 743 571, 744 598" position="743 571" lineWidth="1.0"> <Inputs> <Input id="2031" points="744 515" /> <Input id="2032" stoichiometry="2" points="711 537" /> </Inputs> <Outputs> <Output id="1591" stoichiometry="2" points="706 600" /> <Output id="622" points="744 636" /> </Outputs> <Catalysts> <Catalyst id="4183" points="664 572" /> </Catalysts> <Properties> <displayName>Phosphorylation of cohesin by PLK1 at centromeres</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="658" reactomeId="1638821" points="744 719, 745 738, 745 757" position="745 738" lineWidth="1.0"> <Inputs> <Input id="622" points="744 704" /> <Input id="659" points="795 717" /> </Inputs> <Outputs> <Output id="2872" points="742 778" /> <Output id="661" points="800 757" /> </Outputs> <Catalysts> <Catalyst id="622" points="725 704, 712 725" /> </Catalysts> <Properties> <displayName>PP2A-B56 dephosphorylates centromeric cohesin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1614" reactomeId="2466068" points="520 543, 520 570, 521 602" position="520 570" lineWidth="1.0"> <Inputs> <Input id="2028" points="521 516" /> <Input id="2029" stoichiometry="2" points="488 539" /> </Inputs> <Outputs> <Output id="1616" stoichiometry="2" points="478 605" /> <Output id="624" points="521 648" /> </Outputs> <Catalysts> <Catalyst id="4183" points="561 571" /> </Catalysts> <Properties> <displayName>Phosphorylation of cohesin by PLK1 at chromosomal arms</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1617" reactomeId="2467794" points="522 705, 524 737, 524 749" position="524 737" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="624" /> </Inputs> <Outputs> <Output id="2336" points="447 743" /> <Output id="2349" points="404 780" /> <Output id="1619" stoichiometry="2" points="524 814" /> </Outputs> <Properties> <displayName>Resolution of sister chromatids</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2069" reactomeId="2468293" points="519 376, 519 397, 519 421" position="519 397" lineWidth="1.0"> <Inputs> <Input id="2070" stoichiometry="3" points="471 377" /> <Input id="619" points="518 356" /> </Inputs> <Outputs> <Output id="2071" stoichiometry="3" points="471 426" /> <Output id="2028" points="520 461" /> </Outputs> <Catalysts> <Catalyst id="2072" points="576 396" /> </Catalysts> <Properties> <displayName>CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2122" reactomeId="2468287" points="743 363, 742 396, 742 418" position="742 396" lineWidth="1.0"> <Inputs> <Input id="2474" points="744 321" /> <Input id="2502" stoichiometry="3" points="787 365" /> </Inputs> <Outputs> <Output id="2031" points="743 457" /> <Output id="2125" stoichiometry="3" points="785 418" /> </Outputs> <Catalysts> <Catalyst id="2072" points="687 396" /> </Catalysts> <Properties> <displayName>CDK1 phosphorylates CDCA5 (Sororin) at centromeres</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2164" interactionType="Activate" points="517 142, 517 273" position="517 207" lineWidth="2.0"> <Inputs> <Input id="1646" /> </Inputs> <Outputs> <Output id="619" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2165" interactionType="Activate" points="568 113, 645 111" position="606 112" lineWidth="2.0"> <Inputs> <Input id="1646" /> </Inputs> <Outputs> <Output id="2123" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2473" reactomeId="2484822" points="746 165, 747 193, 747 223" position="747 193" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2123" points="744 132" /> <Input id="21" stoichiometry="2" points="927 192" /> </Inputs> <Outputs> <Output id="2474" /> </Outputs> <Properties> <displayName>Kinetochore assembly</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3138" reactomeId="2514854" points="983 473, 983 492, 984 516" position="983 492" lineWidth="1.0"> <Inputs> <Input id="3140" points="983 452" /> <Input id="3258" stoichiometry="6" points="1010 469" /> </Inputs> <Outputs> <Output id="3271" stoichiometry="6" points="1022 518" /> <Output id="3142" points="984 537" /> </Outputs> <Catalysts> <Catalyst id="2072" points="687 390, 773 379" /> </Catalysts> <Properties> <displayName>CDK1 phosphorylates condensin I</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3191" reactomeId="2520883" points="982 657, 982 678, 981 705" position="982 678" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3192" /> </Inputs> <Outputs> <Output id="3193" /> </Outputs> <Activators> <Activator id="3142" points="1039 561, 1058 561, 1058 678" /> </Activators> <Properties> <displayName>Phosphorylated condensin I promotes condensation of prometaphase chromosomes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3632" reactomeId="2529015" points="981 361, 981 383, 981 399" position="981 383" lineWidth="1.0"> <Inputs> <Input id="3633" points="981 347" /> <Input id="3634" stoichiometry="4" points="946 360" /> </Inputs> <Outputs> <Output id="3140" points="982 424" /> <Output id="3637" stoichiometry="6" points="943 399" /> </Outputs> <Catalysts> <Catalyst id="3635" points="1030 382" /> </Catalysts> <Properties> <displayName>Dephosphorylation of CK2-modified condensin I</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3664" reactomeId="2529020" points="1145 436, 1144 377, 1143 318" position="1144 377" lineWidth="1.0"> <Inputs> <Input id="3665" stoichiometry="4" points="1182 436" /> <Input id="3140" points="1027 437" /> </Inputs> <Outputs> <Output id="3633" points="1037 318" /> <Output id="3666" stoichiometry="4" points="1186 319" /> </Outputs> <Catalysts> <Catalyst id="3667" points="1175 375" /> </Catalysts> <Properties> <displayName>CK2 phosphorylates condensin I subunits</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3800" reactomeId="2545253" points="314 738, 289 739, 270 738" position="289 739" lineWidth="1.0"> <Inputs> <Input id="3801" stoichiometry="2" points="327 716" /> <Input id="2336" points="341 738" /> </Inputs> <Outputs> <Output id="3802" points="222 738" /> <Output id="3803" stoichiometry="2" points="246 711" /> </Outputs> <Catalysts> <Catalyst id="3804" points="289 674" /> </Catalysts> <Properties> <displayName>Deacetylation of cohesin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3860" interactionType="Activate" points="832 811, 976 811" position="904 811" lineWidth="2.0"> <Inputs> <Input id="2872" /> </Inputs> <Outputs> <Output id="3859" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3861" interactionType="Activate" points="1023 761, 1074 788" position="1048 774" lineWidth="2.0"> <Inputs> <Input id="3193" /> </Inputs> <Outputs> <Output id="3859" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="3881" reactomeId="380508" points="224 212, 226 241, 226 266" position="226 241" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3882" points="192 192" /> <Input id="3887" points="261 185" /> </Inputs> <Outputs> <Output id="3884" /> </Outputs> <Properties> <displayName>Translocation of NuMA to the centrosomes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3905" interactionType="Activate" points="149 100, 149 143" position="149 121" lineWidth="2.0"> <Inputs> <Input id="3904" /> </Inputs> <Outputs> <Output id="3882" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="3938" reactomeId="380511" points="230 508, 232 529, 259 539" position="232 529" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3939" points="150 493" /> <Input id="3940" points="166 526" /> <Input id="3886" points="233 465" /> </Inputs> <Outputs> <Output id="3941" /> </Outputs> <Properties> <displayName>Assembly of the NuMA:Dynactin Dynein complex on microtubules</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3943" reactomeId="380316" points="281 343, 280 383, 256 408" position="280 383" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3944" points="1083 72, 424 72, 368 313" /> <Input id="3884" points="251 319" /> </Inputs> <Outputs> <Output id="3886" /> </Outputs> <Properties> <displayName>Association of NuMA with microtubules</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3945" reactomeId="375302" points="996 117, 995 147, 995 181" position="995 147" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="20" points="957 115" /> <Input id="3944" stoichiometry="15" points="1098 86" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> <Properties> <displayName>Kinetochore capture of astral microtubules</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3963" reactomeId="9647746" points="1213 228, 1287 228, 1327 226" position="1287 228" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3964" stoichiometry="3" /> </Inputs> <Outputs> <Output id="3965" /> </Outputs> <Properties> <displayName>EML4 trimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3966" reactomeId="9648017" points="1281 200, 1281 154, 1276 106" position="1281 154" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3944" points="1142 86" /> <Input id="3965" points="1339 211" /> </Inputs> <Outputs> <Output id="3967" /> </Outputs> <Inhibitors> <Inhibitor id="4179" points="1492 130" /> </Inhibitors> <Properties> <displayName>EML4 binds to microtubules</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4082" reactomeId="9648089" points="1492 225, 1552 226, 1617 221" position="1552 226" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="3965" points="1444 225" /> <Input id="4083" stoichiometry="6" points="1473 187" /> </Inputs> <Outputs> <Output id="4084" points="1661 217" /> <Output id="4085" stoichiometry="6" points="1632 180" /> </Outputs> <Catalysts> <Catalyst id="4179" points="1551 152" /> </Catalysts> <Properties> <displayName>NEK6 and NEK7 phosphorylate EML4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4134" reactomeId="156682" points="1714 303, 1673 308, 1630 308" position="1673 308" lineWidth="1.0"> <Inputs> <Input id="4135" stoichiometry="2" points="1738 347" /> <Input id="4136" points="1769 302" /> </Inputs> <Outputs> <Output id="4137" points="1584 308" /> <Output id="4138" stoichiometry="2" points="1600 351" /> </Outputs> <Catalysts> <Catalyst id="4139" points="1678 425" /> </Catalysts> <Properties> <displayName>PLK1 phosphorylates NUDC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4177" reactomeId="9648114" points="1333 331, 1337 361, 1342 413" position="1337 361" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="21" points="1042 223" /> <Input id="4137" points="1448 317" /> <Input id="3965" points="1379 239" /> </Inputs> <Outputs> <Output id="4178" /> </Outputs> <Properties> <displayName>EML4 recruits NUDC to mitotic spindle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="4181" interactionType="Activate" points="149 58, 148 31, 1550 35, 1550 96" position="849 33" lineWidth="2.0"> <Inputs> <Input id="3904" /> </Inputs> <Outputs> <Output id="4179" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="4188" reactomeId="9851946" points="1217 584, 1247 592, 1280 593" position="1247 592" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4189" points="1179 593" /> <Input id="4196" points="1189 552" /> </Inputs> <Outputs> <Output id="4190" /> </Outputs> <Properties> <displayName>FIRRM binds PLK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4191" reactomeId="9851972" points="1439 597, 1466 605, 1500 602" position="1466 605" lineWidth="1.0"> <Inputs> <Input id="4190" points="1418 596" /> <Input id="4192" points="1425 621" /> </Inputs> <Outputs> <Output id="4193" points="1537 597" /> <Output id="4194" points="1515 632" /> </Outputs> <Catalysts> <Catalyst id="4190" points="1418 581, 1450 575" /> </Catalysts> <Properties> <displayName>PLK1 phosphorylates FIRRM at S43</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4205" reactomeId="9853372" points="1179 656, 1216 675, 1260 685" position="1216 675" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4189" points="1158 614" /> <Input id="4206" points="1153 668" /> </Inputs> <Outputs> <Output id="4207" /> </Outputs> <Properties> <displayName>FIRRM binds PPP1CC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4216" reactomeId="9853385" points="1091 717, 1136 737, 1175 745" position="1136 737" lineWidth="1.0"> <Inputs> <Input id="4196" points="1130 542, 1100 545" /> <Input id="4217" points="1079 741" /> </Inputs> <Outputs> <Output id="4218" points="1246 740" /> <Output id="4220" points="1259 766" /> </Outputs> <Catalysts> <Catalyst id="4206" points="1134 697" /> </Catalysts> <Inhibitors> <Inhibitor id="4207" points="1252 709" /> </Inhibitors> <Properties> <displayName>PPP1CC dephosphorylates PLK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4241" reactomeId="9853369" points="1583 667, 1579 700, 1575 757" position="1579 700" lineWidth="1.0"> <Inputs> <Input id="4193" points="1585 614" /> <Input id="4242" points="1607 666" /> </Inputs> <Outputs> <Output id="4243" points="1516 757" /> <Output id="4250" points="1643 730" /> <Output id="4196" points="1186 552, 1227 636, 1558 696" /> </Outputs> <Catalysts> <Catalyst id="4193" points="1579 614, 1563 660" /> </Catalysts> <Properties> <displayName>PLK1 phosphorylates FIRMM at S744</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Mitotic Prometaphase (2294586)
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