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Details on Person UniProt:Q80U16-6 Ripor2
| Class:Id | ReferenceIsoform:229099 |
|---|---|
| _chainChangeLog | chain:1-1078 added on Fri February 6 2015 |
| _displayName | UniProt:Q80U16-6 Ripor2 |
| _timestamp | 2025-08-15 22:16:44 |
| chain | chain:1-1078 |
| checksum | 207E1F6172144E2C |
| comment | FUNCTION Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:25588844, PubMed:27269051). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (PubMed:25588844). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (PubMed:27269051). Plays a role for maintaining the structural organization of the basal domain of stereocilia (PubMed:27269051). Involved in mechanosensory hair cell function (PubMed:27269051). Required for normal hearing (PubMed:27269051).SUBUNIT Homooligomer; homooligomerization is regulated by RHOC and leads to the formation of concatemers through the association of N- and C-termini (PubMed:27269051, PubMed:32631815). Interacts (phosphorylated form) with 14-3-3 proteins; these interactions occur during myogenic cell differentiation and also induces T cell proliferation arrest (By similarity). Interacts (phosphorylated form) with HDAC6; this interaction occurs during early myogenic differentiation, prevents HDAC6 to deacetylate tubulin and also induces T cell proliferation arrest (By similarity). Interacts with DYSF; this interaction occurs during early myogenic differentiation (PubMed:24687993). Interacts with MYOF (By similarity). Interacts (via active GTP- or inactive GDP-bound forms) with RHOA; this interaction is direct, blocks the loading of GTP to RHOA and decreases upon chemokine CCL19 stimulation in primary T lymphocytes (PubMed:27269051). Interacts with RHOC (PubMed:27269051, PubMed:32631815). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with YWHAE (By similarity). Interacts with YWHAQ (By similarity).SUBCELLULAR LOCATION Localized in the cytoplasm in cells undergoing mitosis (By similarity). Colocalized with F-actin (By similarity). Accumulates at the leading edge of polarized neutrophils in a chemokine-dependent manner (By similarity). Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region (PubMed:27269051). Detected in punctate pattern forming a circumferential ring at the stereocilia base (PubMed:27269051). Localized to the apical stereocilia of inner and outer hair cells (By similarity). Not detected as a membrane-associated protein in stereocilia (PubMed:27269051).ALTERNATIVE PRODUCTS Expressed in the cochlea (PubMed:24958875, PubMed:32631815). Expressed in inner hair cells and outer hair cells and Hensen's cells (at protein level) (PubMed:27269051, PubMed:32631815). Expressed in the brain, cerebellum, spinal cord, retina, heart, spleen liver, kidney, bladder, muscle and lung (PubMed:24958875, PubMed:27269051). Expressed in the cochlea of the inner ear (PubMed:24958875, PubMed:27269051).INDUCTION Up-regulated during regenerating muscle tissue.PTM Phosphorylated. Chemokine-induced phosphorylation in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization. Phosphorylated by PKCA, AKT1 and MAPKAPK1A; in vitro.DISRUPTION PHENOTYPE Mice are deaf at 4 weeks of age (PubMed:27269051). Show abnormal hair bundle morphology and polarity and stereociliary growth in the cochlea of the inner ear (PubMed:27269051). Display mislocalization of protein TPRN to the base of stereocilia (PubMed:27269051). Show reduced mechanotransduction currents in hair bundles of outer hair cells (PubMed:27269051). Mice show impaired neutrophil chemotaxis, increased neutrophil adhesion to endothelial cell and reduced neutrophil infiltration into inflamed peritonea (PubMed:25588844). Display increased chemokine-induced RHOA activity and mislocalization of myosin light chain MYL2 in neutrophils (PubMed:25588844).SIMILARITY Belongs to the RIPOR family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="2"Rho family-interacting cell polarization regulator 2 |
| geneName | Ripor2 Fam65b Kiaa0386 |
| identifier | Q80U16 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell adhesion Cell membrane Cell projection Chemotaxis Coiled coil Cytoplasm Cytoskeleton Differentiation Hearing Membrane Myogenesis Phosphoprotein Reference proteome Signal transduction inhibitor |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Ripor2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RIPR2_MOUSE A6PW01 A6PW03 Q3TQ58 Q5SY29 Q5SZV4 Q5T0J1 Q8BIM7 Q8BJ19 Q8BJ22 Q8BJ32 Q8BJ54 |
| sequenceLength | 1078 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q80U16-6 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q80U16-6 Ripor2 (229099)
