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Details on Person UniProt:Q9NPA8 ENY2

Class:Id	ReferenceGeneProduct:228375
_chainChangeLog	chain:1-101 added on Fri February 6 2015
_displayName	UniProt:Q9NPA8 ENY2
_timestamp	2024-11-03 20:09:50
chain	chain:1-101
checksum	A0617024C59AABFB
comment	FUNCTION Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).SUBUNIT Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, the isoform GANP of the MCM3AP gene, PCID2, SEM1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (PubMed:22307388, PubMed:23591820). Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H/SPT3, TAF10, TRRAP and USP22 (PubMed:18206972, PubMed:21746879, PubMed:23591820, PubMed:27601583). Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module) (PubMed:18206972, PubMed:21746879, PubMed:27601583). Interacts with RNA polymerase II subunit POLR2A (PubMed:22307388). Interacts with ATXN7L3B (PubMed:27601583).INTERACTION Localization at the nuclear pore complex requires NUP153 and TPR.ALTERNATIVE PRODUCTS Belongs to the ENY2 family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: fullName evidence="1"Transcription and mRNA export factor ENY2 alternativeName: fullName evidence="1"Enhancer of yellow 2 transcription factor homolog
geneName	ENY2 DC6
identifier	Q9NPA8
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Activator Alternative splicing Chromatin regulator Isopeptide bond mRNA transport Nucleus Protein transport Proteomics identification Reference proteome Transcription Transcription regulation Translocation Transport Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	ENY2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9001745] ENSEMBL:ENSG00000120533 ENY2 [Homo sapiens]
secondaryIdentifier	ENY2_HUMAN B2RE52 G3V117
sequenceLength	101
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8966068] UniProt:Q9NPA8-1 ENY2 [Homo sapiens] [ReferenceIsoform:8966069] UniProt:Q9NPA8-2 ENY2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:3662287] ENY2 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9NPA8 ENY2 (228375)