Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Defective ARSB does not hydrolyse C4S/C6S chains

Class:Id	FailedReaction:2282889
_displayName	Defective ARSB does not hydrolyse C4S/C6S chains
_doRelease	TRUE
_timestamp	2018-01-29 15:14:15
authored	[InstanceEdit:2282887] Jassal, B, 2012-05-28
catalystActivity	[CatalystActivity:9631784] N-acetylgalactosamine-4-sulfatase activity of ARSB mutants:Ca2+ [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:2282887] Jassal, B, 2012-05-28
disease	[Disease:2326770] mucopolysaccharidosis VI
edited	[InstanceEdit:2282887] Jassal, B, 2012-05-28
entityFunctionalStatus	[EntityFunctionalStatus:2282890] loss_of_function of ARSB mutants:Ca2+ [lysosomal lumen]
input	[SimpleEntity:1605715] H2O [lysosomal lumen] [DefinedSet:2065251] C4S/C6S chains [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:2314594] Mutational analysis of mucopolysaccharidosis type VI patients undergoing a trial of enzyme replacement therapy [LiteratureReference:2314599] Maroteaux-lamy syndrome: five novel mutations and their structural localization [LiteratureReference:2314582] Mucopolysaccharidosis type VI: identification of three mutations in the arylsulfatase B gene of patients with the severe and mild phenotypes provides molecular evidence for genetic heterogeneity [LiteratureReference:2314581] Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes [LiteratureReference:2314580] Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patients
modified	[InstanceEdit:2314587] Jassal, B, 2012-06-07 [InstanceEdit:2318591] Jassal, B, 2012-06-14 [InstanceEdit:2318607] Jassal, B, 2012-06-14 [InstanceEdit:2318608] Jassal, B, 2012-06-14 [InstanceEdit:2318609] Jassal, B, 2012-06-14 [InstanceEdit:2326769] Jassal, B, 2012-06-19 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2454166] Jassal, B, 2012-08-22 [InstanceEdit:2457601] Jassal, B, 2012-08-24 [InstanceEdit:2457639] Jassal, B, 2012-08-27 [InstanceEdit:2457642] Jassal, B, 2012-08-27 [InstanceEdit:2457648] Jassal, B, 2012-08-27 [InstanceEdit:5671966] Jassal, Bijay, 2015-02-03 [InstanceEdit:9036066] Jassal, Bijay, 2018-01-29 [InstanceEdit:9631717] Wu, G, 2018-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective ARSB does not hydrolyse C4S/C6S chains
normalReaction	[Reaction:1793207] ARSB hydrolyses C4S/C6S chains [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2457644] Coutinho, Maria, 2012-08-27 [InstanceEdit:2457645] Alves, Sandra, 2012-08-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2465015] R-HSA-2282889.4
summation	[Summation:2314579] Arylsulfatase B using calcium cofactor (ARSB:Ca2+) hydrolys...
(hasEvent)	[Pathway:2206285] MPS VI - Maroteaux-Lamy syndrome [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778212] Update Tracker - [FailedReaction:2282889] Defective ARSB does not hydrolyse C4S/C6S chains - v68:[addCatalystActivity] [_UpdateTracker:9779721] Update Tracker - [FailedReaction:2282889] Defective ARSB does not hydrolyse C4S/C6S chains - v64:[add_removeInput, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by Defective ARSB does not hydrolyse C4S/C6S chains (2282889)