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Details on Person UniProt:Q9NYP7 ELOVL5

Class:Id	ReferenceGeneProduct:228201
_chainChangeLog	chain:1-299 added on Fri February 6 2015
_displayName	UniProt:Q9NYP7 ELOVL5
_timestamp	2026-02-20 21:39:16
chain	chain:1-299
checksum	AE5150AA3432E984
comment	FUNCTION Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:10970790, PubMed:20937905). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).CATALYTIC ACTIVITY a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoACATALYTIC ACTIVITY (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (11Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + malonyl-CoA + H(+) = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoACATALYTIC ACTIVITY (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoAPATHWAY Lipid metabolism; polyunsaturated fatty acid biosynthesis.SUBUNIT Interacts with TECR.INTERACTION In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree.ALTERNATIVE PRODUCTS Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ELO family. ELOVL5 subfamily.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: fullName evidence="2"Very long chain fatty acid elongase 5 ecNumber evidence="2 4 5 6"2.3.1.199 alternativeName: fullName evidence="2"3-keto acyl-CoA synthase ELOVL5 alternativeName: fullName evidence="2"ELOVL fatty acid elongase 5 shortName evidence="2"ELOVL FA elongase 5 alternativeName: fullName evidence="2"Elongation of very long chain fatty acids protein 5 alternativeName: Fatty acid elongase 1 shortName: hELO1 alternativeName: fullName evidence="2"Very long chain 3-ketoacyl-CoA synthase 5 alternativeName: fullName evidence="2"Very long chain 3-oxoacyl-CoA synthase 5
geneName	ELOVL5 ELOVL2 PRO0530
identifier	Q9NYP7
isSequenceChanged	FALSE
keyword	Acetylation Alternative splicing Cell projection Disease variant Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Membrane Neurodegeneration Phosphoprotein Proteomics identification Reference proteome Spinocerebellar ataxia Transferase Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	ELOVL5
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8962544] ENSEMBL:ENSG00000012660 ELOVL5 [Homo sapiens]
secondaryIdentifier	ELOV5_HUMAN B4DZJ2 F6SH78 Q59EL3 Q5TGH5 Q6NXE7 Q7L2S5 Q8NCG4 Q9UI22
sequenceLength	299
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8968268] UniProt:Q9NYP7-1 ELOVL5 [Homo sapiens] [ReferenceIsoform:8968269] UniProt:Q9NYP7-2 ELOVL5 [Homo sapiens] [ReferenceIsoform:8968270] UniProt:Q9NYP7-3 ELOVL5 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:548679] ELOVL5 [endoplasmic reticulum membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9NYP7 ELOVL5 (228201)