Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q9H228 S1PR5

Class:Id	ReferenceGeneProduct:227932
_chainChangeLog	chain:1-398 added on Fri February 6 2015
_displayName	UniProt:Q9H228 S1PR5
_timestamp	2024-11-03 20:07:33
chain	chain:1-398
checksum	34ADC6C40D8250BF
comment	FUNCTION Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.INTERACTION Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.DEVELOPMENTAL STAGE At 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain immunolabeled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found.SIMILARITY Belongs to the G-protein coupled receptor 1 family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Sphingosine 1-phosphate receptor 5 shortName: S1P receptor 5 shortName: S1P5 alternativeName: Endothelial differentiation G-protein-coupled receptor 8 alternativeName: Sphingosine 1-phosphate receptor Edg-8 shortName: S1P receptor Edg-8
geneName	S1PR5 EDG8
identifier	Q9H228
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell membrane G-protein coupled receptor Glycoprotein Lipoprotein Membrane Palmitate Phosphoprotein Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	S1PR5
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8990961] ENSEMBL:ENSG00000180739 S1PR5 [Homo sapiens]
secondaryIdentifier	S1PR5_HUMAN Q6NW11
sequenceLength	398
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:227933] UniProt:Q9H228-2 S1PR5 [Homo sapiens] [ReferenceIsoform:414182] UniProt:Q9H228-1 S1PR5 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:419420] S1PR5 [plasma membrane] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q9H228 S1PR5 (227932)