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Details on Person UniProt:A0AVK6 E2F8
| Class:Id | ReferenceGeneProduct:227807 |
|---|---|
| _chainChangeLog | chain:1-867 added on Sat February 7 2015 |
| _displayName | UniProt:A0AVK6 E2F8 |
| _timestamp | 2024-11-03 20:14:12 |
| chain | chain:1-867 |
| checksum | AADBCFACB888BD93 |
| comment | FUNCTION Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.SUBUNIT Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding. Interacts with HIF1A.INTERACTION Following DNA damage (PubMed:18202719). Up-regulation in response to DNA damage is not confirmed by PubMed:22802528.DOMAIN In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).SIMILARITY Belongs to the E2F/DP family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Transcription factor E2F8 shortName: E2F-8 |
| geneName | E2F8 |
| identifier | A0AVK6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Cell cycle DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | E2F8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962341] ENSEMBL:ENSG00000129173 E2F8 [Homo sapiens] |
| secondaryIdentifier | E2F8_HUMAN A8K9H3 Q2VPJ3 Q3C1U6 Q5BKY4 Q8N340 Q9H5M0 |
| sequenceLength | 867 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8952990] E2F8 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:A0AVK6 E2F8 (227807)
