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Details on Person UniProt:Q9Y2E6 DTX4
| Class:Id | ReferenceGeneProduct:227617 |
|---|---|
| _chainChangeLog | chain:1-619 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y2E6 DTX4 |
| _timestamp | 2024-11-03 19:55:58 |
| chain | chain:1-619 |
| checksum | 5C851845B42630BD |
| comment | FUNCTION Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with NLRP4.SUBCELLULAR LOCATION The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.SIMILARITY Belongs to the Deltex family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: E3 ubiquitin-protein ligase DTX4 ecNumber evidence="2"2.3.2.27 alternativeName: Protein deltex-4 shortName: Deltex4 alternativeName: RING finger protein 155 alternativeName: fullName evidence="8"RING-type E3 ubiquitin transferase DTX4 |
| geneName | DTX4 KIAA0937 RNF155 |
| identifier | Q9Y2E6 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Metal-binding Notch signaling pathway Proteomics identification Reference proteome Repeat Transferase Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DTX4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998858] ENSEMBL:ENSG00000110042 DTX4 [Homo sapiens] |
| secondaryIdentifier | DTX4_HUMAN Q0VF38 |
| sequenceLength | 619 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:227618] UniProt:Q9Y2E6-2 DTX4 [Homo sapiens] [ReferenceIsoform:415939] UniProt:Q9Y2E6-1 DTX4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1604439] DTX4 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y2E6 DTX4 (227617)
