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Details on Person UniProt:Q4LDG9 DNAL1
| Class:Id | ReferenceGeneProduct:227283 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-190 added on Sat February 7 2015;initiator methionine:1 for 227283 removed on Fri Nov 03 2023;initiator methionine: for 227283 added on Fri Nov 03 2023;initiator methionine: for 227283 removed on Fri Aug 15 2025;initiator methionine:1 for 227283 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q4LDG9 DNAL1 |
| _timestamp | 2025-08-15 22:00:02 |
| chain | initiator methionine:1 chain:2-190 |
| checksum | A48EA5047F6721EE |
| comment | FUNCTION Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (PubMed:21496787).SUBUNIT Interacts with ZMYND10 (via C-terminus) (PubMed:29601588). Interacts with DNAH5, a outer arm dynein heavy chain (PubMed:15845866, PubMed:21496787). Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner (PubMed:21496787).INTERACTION Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.SIMILARITY Belongs to the dynein light chain LC1-type family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Dynein axonemal light chain 1 shortName evidence="2"LC1 |
| geneName | DNAL1 C14orf168 |
| identifier | Q4LDG9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell projection Ciliopathy Cytoplasm Cytoskeleton Disease variant Dynein Kartagener syndrome Leucine-rich repeat Microtubule Motor protein Phosphoprotein Primary ciliary dyskinesia Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DNAL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962337] ENSEMBL:ENSG00000119661 DNAL1 [Homo sapiens] |
| secondaryIdentifier | DNAL1_HUMAN B2RD38 Q5JPB7 Q9BS43 |
| sequenceLength | 190 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:227284] UniProt:Q4LDG9-2 DNAL1 [Homo sapiens] [ReferenceIsoform:406883] UniProt:Q4LDG9-1 DNAL1 [Homo sapiens] [ReferenceIsoform:8966524] UniProt:Q4LDG9-3 DNAL1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9966721] DNAL1 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969291] DNAL1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q4LDG9 DNAL1 (227283)
