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Details on Person UniProt:Q5U458 Dnajc11
| Class:Id | ReferenceGeneProduct:227130 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-559 added on Fri February 6 2015;initiator methionine:1 for 227130 removed on Fri Nov 03 2023;initiator methionine: for 227130 added on Fri Nov 03 2023;initiator methionine: for 227130 removed on Fri Aug 15 2025;initiator methionine:1 for 227130 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q5U458 Dnajc11 |
| _timestamp | 2025-08-15 20:59:09 |
| chain | initiator methionine:1 chain:2-559 |
| checksum | DA6B7590EC7D2561 |
| comment | FUNCTION Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.SUBUNIT Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.SUBCELLULAR LOCATION Following chemical mutagenesis predicted to give rise to a transcript subject to non-sense mediated deccay, mice exhibit an autosomal recessive neuromuscular disease and abnormal mitochondrial cristae morphology.SIMILARITY Belongs to the DNAJC11 family.SEQUENCE CAUTION Probable cloning artifact. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: DnaJ homolog subfamily C member 11 |
| geneName | Dnajc11 |
| identifier | Q5U458 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Chaperone Coiled coil Membrane Mitochondrion Mitochondrion outer membrane Phosphoprotein Reference proteome |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Dnajc11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DJC11_MOUSE A2A8C9 Q8BP83 Q8C1Z4 Q8C6U5 |
| sequenceLength | 559 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:8949596] Dnajc11 [mitochondrial outer membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q5U458 Dnajc11 (227130)
