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Details on Person UniProt:Q8CI75 Dis3l2
| Class:Id | ReferenceGeneProduct:227034 |
|---|---|
| _chainChangeLog | chain:1-870 added on Fri February 6 2015 |
| _displayName | UniProt:Q8CI75 Dis3l2 |
| _timestamp | 2023-11-03 17:58:58 |
| chain | chain:1-870 |
| checksum | E54474450DCD363F |
| comment | FUNCTION 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.COFACTOR Interacts with XRN1.INTERACTION Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.SIMILARITY Belongs to the RNR ribonuclease family. DIS3L2 subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="2"DIS3-like exonuclease 2 ecNumber evidence="2"3.1.13.- |
| geneName | Dis3l2 |
| identifier | Q8CI75 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Cytoplasm Exonuclease Hydrolase Magnesium Metal-binding Mitosis Nuclease Phosphoprotein Reference proteome RNA-binding Tumor suppressor |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Dis3l2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DI3L2_MOUSE Q8BMG9 |
| sequenceLength | 870 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:227035] UniProt:Q8CI75-2 Dis3l2 [Mus musculus] [ReferenceIsoform:410690] UniProt:Q8CI75-1 Dis3l2 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9820873] Dis3l2 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8CI75 Dis3l2 (227034)
