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Details on Person UniProt:Q8NBQ5 HSD17B11
| Class:Id | ReferenceGeneProduct:226916 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Sat February 7 2015;chain:20-300 added on Sat February 7 2015 |
| _displayName | UniProt:Q8NBQ5 HSD17B11 |
| _timestamp | 2025-02-21 19:26:59 |
| chain | signal peptide:1-19 chain:20-300 |
| checksum | 51DC0EAA205EBE86 |
| comment | FUNCTION Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.CATALYTIC ACTIVITY 17beta-estradiol + NAD(+) = estrone + NADH + H(+)CATALYTIC ACTIVITY 17beta-estradiol + NADP(+) = estrone + NADPH + H(+)INTERACTION Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation.TISSUE SPECIFICITY Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Estradiol 17-beta-dehydrogenase 11 ecNumber: 1.1.1.62 alternativeName: 17-beta-hydroxysteroid dehydrogenase 11 shortName: 17-beta-HSD 11 shortName: 17bHSD11 shortName: 17betaHSD11 alternativeName: 17-beta-hydroxysteroid dehydrogenase XI shortName: 17-beta-HSD XI shortName evidence="8"17betaHSDXI alternativeName: Cutaneous T-cell lymphoma-associated antigen HD-CL-03 shortName: CTCL-associated antigen HD-CL-03 alternativeName: Dehydrogenase/reductase SDR family member 8 alternativeName: Retinal short-chain dehydrogenase/reductase 2 shortName: retSDR2 alternativeName: Short chain dehydrogenase/reductase family 16C member 2 |
| geneName | HSD17B11 DHRS8 PAN1B SDR16C2 PSEC0029 UNQ207/PRO233 |
| identifier | Q8NBQ5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Endoplasmic reticulum Lipid biosynthesis Lipid droplet Lipid metabolism NADP Oxidoreductase Proteomics identification Reference proteome Signal Steroid biosynthesis |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | HSD17B11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992405] ENSEMBL:ENSG00000198189 HSD17B11 [Homo sapiens] |
| secondaryIdentifier | DHB11_HUMAN Q96HF6 Q9UKU4 |
| sequenceLength | 300 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5693370] HSD17B11 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8NBQ5 HSD17B11 (226916)
