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Details on Person UniProt:A2RUS2 DENND3
| Class:Id | ReferenceGeneProduct:226825 |
|---|---|
| _chainChangeLog | chain:1-1198 added on Fri February 6 2015 |
| _displayName | UniProt:A2RUS2 DENND3 |
| _timestamp | 2024-11-03 20:14:00 |
| chain | chain:1-1198 |
| checksum | 52D51635DDD88A4E |
| comment | FUNCTION Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).SUBUNIT Forms oligomers. Interacts with 6 of the 7 known isoforms of 14-3-3 proteins.SUBCELLULAR LOCATION Transiently recruited to membranes to activate RAB12.ALTERNATIVE PRODUCTS Inactive DENND3 is found in a closed conformation, in which the linker region interacts with the DENN domain. Phosphorylation of Tyr-858 in the linker region intereferes with this interaction leading to an open conformation and enhances the GEF activity of the protein towards RAB12. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: DENN domain-containing protein 3 |
| geneName | DENND3 KIAA0870 |
| identifier | A2RUS2 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Guanine-nucleotide releasing factor Phosphoprotein Proteomics identification Reference proteome Repeat WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DENND3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961064] ENSEMBL:ENSG00000105339 DENND3 [Homo sapiens] |
| secondaryIdentifier | DEND3_HUMAN B7ZM28 O94947 Q2TAM7 Q6ZMS6 Q96DK3 |
| sequenceLength | 1198 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:226826] UniProt:A2RUS2-2 DENND3 [Homo sapiens] [ReferenceIsoform:226827] UniProt:A2RUS2-3 DENND3 [Homo sapiens] [ReferenceIsoform:226828] UniProt:A2RUS2-4 DENND3 [Homo sapiens] [ReferenceIsoform:400869] UniProt:A2RUS2-1 DENND3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8876434] p-S472,S490-DENND3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8876435] DENND3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8961275] DENND3 [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8876436] O-phospho-L-serine at 490 [ModifiedResidue:8876438] O-phospho-L-serine at 472 |
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No pathways have been reviewed or authored by UniProt:A2RUS2 DENND3 (226825)
