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Details on Person UniProt:Q9Y6V7 DDX49
| Class:Id | ReferenceGeneProduct:226722 |
|---|---|
| _chainChangeLog | chain:1-483 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y6V7 DDX49 |
| _timestamp | 2026-02-20 22:08:39 |
| chain | chain:1-483 |
| checksum | 2B46DD6A992B2532 |
| comment | FUNCTION ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including the regulation of mRNA export and the levels of pre-ribosomal RNA. Regulates the stability and synthesis of pre-ribosomal RNA and thereby regulates cell proliferation (PubMed:29618122). Also possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBCELLULAR LOCATION Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Probable ATP-dependent RNA helicase DDX49 ecNumber: 3.6.4.13 alternativeName: DEAD box protein 49 |
| geneName | DDX49 |
| identifier | Q9Y6V7 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Helicase Hydrolase Nucleotide-binding Nucleus Proteomics identification Reference proteome RNA-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | DDX49 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997669] ENSEMBL:ENSG00000105671 DDX49 [Homo sapiens] |
| secondaryIdentifier | DDX49_HUMAN E7ENA0 Q53FJ1 Q9BVQ8 |
| sequenceLength | 483 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975074] UniProt:Q9Y6V7-1 DDX49 [Homo sapiens] [ReferenceIsoform:8975075] UniProt:Q9Y6V7-2 DDX49 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6790725] DDX49 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y6V7 DDX49 (226722)
