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Details on Person UniProt:P0DJD7 PGA4
| Class:Id | ReferenceGeneProduct:2265949 |
|---|---|
| _chainChangeLog | signal peptide:1-15 added on Fri February 6 2015;propeptide:16-62 added on Fri February 6 2015;chain:63-388 added on Fri February 6 2015 |
| _displayName | UniProt:P0DJD7 PGA4 |
| _timestamp | 2023-11-03 17:00:50 |
| chain | signal peptide:1-15 propeptide:16-62 chain:63-388 |
| checksum | C9CB89BA08F4D78B |
| comment | FUNCTION Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.CATALYTIC ACTIVITY Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.INTERACTION Belongs to the peptidase A1 family. |
| created | [InstanceEdit:2265580] Weiser, JD |
| description | recommendedName: Pepsin A-4 ecNumber: 3.4.23.1 alternativeName: Pepsinogen-4 |
| geneName | PGA4 |
| identifier | P0DJD7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Aspartyl protease Digestion Direct protein sequencing Disulfide bond Hydrolase Phosphoprotein Protease Reference proteome Secreted Signal Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | PGA4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988023] ENSEMBL:ENSG00000229183 PGA4 [Homo sapiens] |
| secondaryIdentifier | PEPA4_HUMAN A8K749 B7ZW75 P00790 Q7M4R0 Q8N1E3 |
| sequenceLength | 388 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5685891] PGA4 [multivesicular body lumen] [Homo sapiens] [EntityWithAccessionedSequence:8984738] PGA4 propeptide [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8984745] proPGA4 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8984761] PGA4 [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P0DJD7 PGA4 (2265949)
