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Details on Person UniProt:B2RUJ5-2 Apba1
| Class:Id | ReferenceIsoform:2265784 |
|---|---|
| _chainChangeLog | chain:1-842 added on Fri February 6 2015 |
| _displayName | UniProt:B2RUJ5-2 Apba1 |
| _timestamp | 2023-11-03 16:50:16 |
| chain | chain:1-842 |
| checksum | E00B754EDCF1B1D4 |
| comment | FUNCTION Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity). Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156).SUBUNIT Part of a multimeric complex containing STXBP1 and STX1A. Interacts with STXBP1 (PubMed:21445306). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (PubMed:10846156). Within the complex, interacts (via PDZ domain) with the motor protein KIF17; the interaction is direct and is required for association of KIF17 with the cargo that is to be transported (PubMed:10846156). Binds to the cytoplasmic domain of amyloid protein (APP) (By similarity). Interacts (via PDZ 1 and 2 domains) with FSPB (By similarity). Isoform 3 interacts (via its truncated PID domain) with active, GTP-bound RAB6A. Also interacts with GTP-bound RAB6B (By similarity).SUBCELLULAR LOCATION Isoform 3 is expressed in brain.DOMAIN Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.DOMAIN The autoinhibitory helix linker occludes the APP binding site.DOMAIN The PID domain, truncated by 11 amino acids, as observed in isoform 3, but not full-length, mediates the interaction with RAB6A.MISCELLANEOUS This isoform interacts with RAB6 GTPases. |
| created | [InstanceEdit:2265580] Weiser, JD |
| description | recommendedName: Amyloid-beta A4 precursor protein-binding family A member 1 alternativeName: Adapter protein X11alpha alternativeName: Neuron-specific X11 protein alternativeName: Neuronal Munc18-1-interacting protein 1 shortName: Mint-1 |
| geneName | Apba1 Mint1 mLin-10 X11 |
| identifier | B2RUJ5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Direct protein sequencing Golgi apparatus Nucleus Phosphoprotein Protein transport Reference proteome Repeat Transport |
| modified | [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Apba1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | APBA1_MOUSE Q3UH49 Q8BMF2 |
| sequenceLength | 842 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | B2RUJ5-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:B2RUJ5-2 Apba1 (2265784)
