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Details on Person UniProt:Q13409-6 DYNC1I2
| Class:Id | ReferenceIsoform:226494 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-638 added on Fri February 6 2015;initiator methionine:1 for 226494 removed on Fri Nov 03 2023;initiator methionine: for 226494 added on Fri Nov 03 2023;initiator methionine: for 226494 removed on Fri Aug 15 2025;initiator methionine:1 for 226494 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q13409-6 DYNC1I2 |
| _timestamp | 2025-08-15 21:14:06 |
| chain | initiator methionine:1 chain:2-638 |
| checksum | 2F868EC9556C47F2 |
| comment | FUNCTION Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity).SUBUNIT Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer (PubMed:29420470, PubMed:36071160). Interacts with DYNLT3 (By similarity). Interacts with DYNLT1 (PubMed:27502274). Interacts (dephosphorylated at Ser-90) with DCTN1 (By similarity). Interacts with BICD2. Interacts with SPEF2 (By similarity). Interacts with CFAP61 (By similarity).SUBUNIT (Microbial infection) Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport.INTERACTION Detected in the cytoplasm of pachytene spermatocytes. Localizes to the manchette in elongating spermatids.ALTERNATIVE PRODUCTS The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.PTM Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) promotes interaction with DCTN1. Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the dynein intermediate chain family.SEQUENCE CAUTION Unlikely isoform. Several sequence problems. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Cytoplasmic dynein 1 intermediate chain 2 alternativeName: Cytoplasmic dynein intermediate chain 2 alternativeName: Dynein intermediate chain 2, cytosolic shortName: DH IC-2 |
| geneName | DYNC1I2 DNCI2 DNCIC2 |
| identifier | Q13409 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Dynein Host-virus interaction Intellectual disability Microtubule Motor protein Phosphoprotein Proteomics identification Reference proteome Repeat Transport WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DYNC1I2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002909] ENSEMBL:ENSG00000077380 DYNC1I2 [Homo sapiens] |
| secondaryIdentifier | DC1I2_HUMAN B7ZA04 D3DPD4 D3DPD5 D3DPD6 Q32LY9 Q53S84 Q5BJF8 Q7Z4X1 Q96NG7 Q96S87 Q9BXZ5 Q9NT58 |
| sequenceLength | 638 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q13409-6 |
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No pathways have been reviewed or authored by UniProt:Q13409-6 DYNC1I2 (226494)
