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Details on Person UniProt:O75553-6 DAB1
| Class:Id | ReferenceIsoform:226363 |
|---|---|
| _chainChangeLog | chain:1-588 added on Sat February 7 2015 |
| _displayName | UniProt:O75553-6 DAB1 |
| _timestamp | 2025-02-21 20:08:00 |
| chain | chain:1-588 |
| checksum | DAD4024364113AC5 |
| comment | FUNCTION Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain.SUBUNIT Associates with the SH2 domains of SRC, FYN and ABL (By similarity). Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain) (By similarity). Interacts with SIAH1, LRP8 and VLDLR (By similarity). Interacts with LRP1 (PubMed:15272003). Interacts with APLP1 (via NPXY motif) (By similarity). Interacts with DAB2IP (By similarity). Interacts with ZSWIM8 (PubMed:35989311).INTERACTION Mainly expressed in brain.DOMAIN The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.PTM Phosphorylated by FYN on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.PTM Ubiquitinated by various cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes) following ligand-binding and phosphorylation, leading to its degradation. Ubiquitinated by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex following ligand-binding and phosphorylation by FYN, leading to its degradation by the proteasome. Recognized by ZSWIM8 through a disorder targets misorder mechanism that eliminates misfolded DAB1 via ubiquitination and proteasomal degradation (PubMed:35989311).DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Disabled homolog 1 |
| geneName | DAB1 |
| identifier | O75553 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Developmental protein Differentiation Neurodegeneration Neurogenesis Phosphoprotein Proteomics identification Reference proteome Spinocerebellar ataxia Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | DAB1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987771] ENSEMBL:ENSG00000173406 DAB1 [Homo sapiens] |
| secondaryIdentifier | DAB1_HUMAN A4FU90 B3KTG3 Q4LE59 Q5T6M6 Q5T6M9 Q5T835 Q5T836 Q5T837 Q6NWS9 Q6NWT0 Q6NWT1 Q9NYA8 |
| sequenceLength | 588 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O75553-6 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75553-6 DAB1 (226363)
