Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]

Class:IdComplex:2262774
_displayNameTRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
_timestamp2018-08-09 02:31:21
compartment[Compartment:876] plasma membrane
created[InstanceEdit:2262776] Shamovsky, V, 2012-05-21
hasComponent
isChimericFALSE
literatureReference[LiteratureReference:450125] IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
[LiteratureReference:2428852] IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
modified[InstanceEdit:2428909] Shamovsky, V, 2012-08-08
[InstanceEdit:8959586] Weiser, JD
[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
nameTRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:MAL:activated TLR
relatedSpecies[Species:181384] Chlamydia trachomatis
[Species:180800] Neisseria meningitidis serogroup B
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2297960] R-HSA-2262774.3
(input)[Reaction:2262775] Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex [Homo sapiens]
(output)[Reaction:2262777] TRAF6 binds to p-IRAK2 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9872969] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[_UpdateTracker:9873554] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v43:[updateContainedComponent]
[_UpdateTracker:9889433] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v49:[updateContainedComponent]
[_UpdateTracker:9891771] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v52:[updateContainedComponent]
[_UpdateTracker:9892797] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v54:[updateContainedComponent]
[_UpdateTracker:9895328] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v59:[updateContainedComponent]
[_UpdateTracker:9896689] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v60:[removeSpecies, updateContainedComponent]
[_UpdateTracker:9899606] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v66:[modifyName, updateContainedComponent]
[_UpdateTracker:9899773] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v67:[updateContainedComponent]
[_UpdateTracker:9902083] Update Tracker - [Complex:2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v76:[updateContainedComponent]
[Change default viewing format]
No pathways have been reviewed or authored by TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (2262774)
Follow Reactome