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Details on Person UniProt:P52569-2 SLC7A2
| Class:Id | ReferenceIsoform:226047 |
|---|---|
| _chainChangeLog | chain:1-658 added on Fri February 6 2015 |
| _displayName | UniProt:P52569-2 SLC7A2 |
| _timestamp | 2024-11-03 19:35:51 |
| chain | chain:1-658 |
| checksum | 633FD86A333E9208 |
| comment | FUNCTION Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity).FUNCTION Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2.FUNCTION Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine).CATALYTIC ACTIVITY L-arginine(in) = L-arginine(out)CATALYTIC ACTIVITY L-arginine(in) = L-arginine(out)CATALYTIC ACTIVITY L-lysine(in) = L-lysine(out)CATALYTIC ACTIVITY L-ornithine(in) = L-ornithine(out)CATALYTIC ACTIVITY L-homoarginine(in) = L-homoarginine(out)CATALYTIC ACTIVITY L-homoarginine(in) = L-homoarginine(out)BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.5 for L-arginine transport.BIOPHYSICOCHEMICAL PROPERTIES In contrast with isoform 1, saturation of L-homoarginine uptake could not be reached.SUBCELLULAR LOCATION Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart.SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="10"Cationic amino acid transporter 2 shortName: CAT-2 shortName: CAT2 alternativeName: Low affinity cationic amino acid transporter 2 alternativeName: Solute carrier family 7 member 2 |
| geneName | SLC7A2 ATRC2 CAT2 |
| identifier | P52569 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Amino-acid transport Cell membrane Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SLC7A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995372] ENSEMBL:ENSG00000003989 SLC7A2 [Homo sapiens] |
| secondaryIdentifier | CTR2_HUMAN B7ZL54 O15291 O15292 Q14CQ6 Q6NSZ7 Q86TC6 |
| sequenceLength | 658 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P52569-2 |
| (referenceEntity) | [EntityWithAccessionedSequence:375802] SLC7A2-2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P52569-2 SLC7A2 (226047)
