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Details on Person UniProt:O95196 CSPG5
Class:Id
ReferenceGeneProduct:225830
_chainChangeLog
signal peptide:1-30 added on Sat February 7 2015;chain:31-566 added on Sat February 7 2015
_displayName
UniProt:O95196 CSPG5
_timestamp
2024-11-03 19:50:36
chain
signal peptide:1-30 chain:31-566
checksum
DD8DA045C1BE31E5
comment
FUNCTION May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.SUBUNIT Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC. Interacts with MDK; this interaction is independent of the presence of chondroitin sulfate chains and promotes elongation of oligodendroglial precursor-like cells (By similarity).INTERACTION In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts.ALTERNATIVE PRODUCTS Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717). Expressed in brain (at protein level) (PubMed:9950058).DEVELOPMENTAL STAGE Expressed in brain of 3 months, 5 and 10-year-old individuals.PTM N-glycosylated.PTM O-glycosylated; contains chondroitin sulfate glycans (PubMed:25326458). Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form (By similarity). The relative amount of both forms depends on tissues and tissue maturation (By similarity).PTM Phosphorylated; in intracellular and extracellular parts.MISCELLANEOUS Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity).
