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Details on Person UniProt:Q9QXT8-2 Kcnip3
| Class:Id | ReferenceIsoform:225758 |
|---|---|
| _chainChangeLog | chain:1-256 added on Fri February 6 2015 |
| _displayName | UniProt:Q9QXT8-2 Kcnip3 |
| _timestamp | 2026-05-15 21:14:25 |
| chain | chain:1-256 |
| checksum | 0F43D5F239D6378C |
| comment | FUNCTION Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.FUNCTION Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.FUNCTION May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity).SUBUNIT Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium (PubMed:18201103). Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1. Component of heteromultimeric potassium channels (PubMed:19713751). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (PubMed:19713751). Interacts with KCND2 and KCND3 (PubMed:11598014, PubMed:12451113, PubMed:20943905).INTERACTION The sumoylated form is present only in the nucleus. In the presence of PSEN2, associated with the endoplasmic reticulum and Golgi.ALTERNATIVE PRODUCTS Highly expressed in brain. Isoform 1 or isoform 4 (T+ forms) are expressed at equal levels with isoform 2 or isoform 3 (T- forms). Primarily detected in the layer V and deep layer VI of the cerebral cortex, the hippocampus, and the entire cerebellum. Expressed at low levels in testis. Also expressed in heart.PTM Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity).PTM Proteolytically cleaved by caspase-3.MISCELLANEOUS Mice deficient for Csen show a significant decrease of amyloid-beta protein 40 and beta-amyloid protein 42, and display markedly reduced responses in models of acute thermal, mechanical, and visceral pain.MISCELLANEOUS Lacks EF-hand domains.SIMILARITY Belongs to the recoverin family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Calsenilin alternativeName: A-type potassium channel modulatory protein 3 alternativeName: DRE-antagonist modulator shortName: DREAM alternativeName: Kv channel-interacting protein 3 shortName: KChIP3 |
| geneName | Kcnip3 Csen Dream Kchip3 |
| identifier | Q9QXT8 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Calcium Cell membrane Cytoplasm Endoplasmic reticulum Golgi apparatus Ion channel Ion transport Isopeptide bond Lipoprotein Membrane Metal-binding Nucleus Palmitate Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Repeat Repressor Transcription Transcription regulation Transport Ubl conjugation Voltage-gated channel |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:435478] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9970787] Weiser, Joel, 2025-10-31 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | Kcnip3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CSEN_MOUSE Q924L0 Q99PH9 Q99PI0 Q99PI2 Q99PI3 Q9JHZ5 |
| sequenceLength | 256 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q9QXT8-2 |
| (isoformParent) | [ReferenceIsoform:402664] UniProt:P0C092-1 Kcnip3 [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9QXT8-2 Kcnip3 (225758)
