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Details on Person UniProt:Q91XE9 Creb3l3
| Class:Id | ReferenceGeneProduct:225455 |
|---|---|
| _chainChangeLog | chain:1-479 added on Fri February 6 2015;chain:1- added on Fri February 6 2015 |
| _displayName | UniProt:Q91XE9 Creb3l3 |
| _timestamp | 2023-11-03 16:01:05 |
| chain | chain:1-479 chain:1- |
| checksum | 948A06FE79DB3779 |
| comment | FUNCTION Transcription factor that may act during endoplasmic reticulum (ER) stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. Binds to the cAMP response element (CRE). Activates transcription through box-B element (By similarity). Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (PubMed:30389664). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694).SUBUNIT Binds DNA as a dimer. May form homodimers (By similarity). Interacts with ATF6 (By similarity). Interacts with SYNV1/HRD1; this interaction leads to CREB3L3 ubiquitination and proteasomal degradation (PubMed:30389664).SUBCELLULAR LOCATION Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.TISSUE SPECIFICITY Expressed in adult liver (at protein level) and small intestine.INDUCTION By IL6. Pro-inflammatory cytokines and lipopolysaccharide activate the UPR and induce cleavage of CREBH in the liver (PubMed:16469704). Down-regulated in the liver during fasting-refeeding. This down-regulation may occur at the postranscriptional level and may be mediated by SYNV1/HRD1, which induces CREB3L3 ubiquitination and proteasomal degradation (PubMed:30389664).PTM Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (By similarity).PTM N-glycosylation is required for optimal proteolytic activation.PTM Ubiquitinated at Lys-290 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin.DISRUPTION PHENOTYPE Knockout mice display decreased triglyceride clearance from plasma resulting in hypertriglyceridemia.SIMILARITY Belongs to the bZIP family. ATF subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Cyclic AMP-responsive element-binding protein 3-like protein 3 shortName: cAMP-responsive element-binding protein 3-like protein 3 alternativeName: Transcription factor CREB-H component recommendedName: Processed cyclic AMP-responsive element-binding protein 3-like protein 3 /component |
| geneName | Creb3l3 Crebh |
| identifier | Q91XE9 |
| isSequenceChanged | FALSE |
| keyword | Activator DNA-binding Endoplasmic reticulum Glycoprotein Isopeptide bond Membrane Nucleus Reference proteome Signal-anchor Transcription Transcription regulation Transmembrane Transmembrane helix Ubl conjugation Unfolded protein response |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Creb3l3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CR3L3_MOUSE Q8BWS0 |
| sequenceLength | 479 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:6784647] Creb3l3(1-?) [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:6784660] Creb3l3 [endoplasmic reticulum membrane] [Mus musculus] [EntityWithAccessionedSequence:6784689] Creb3l3(?-479) [endoplasmic reticulum membrane] [Mus musculus] [EntityWithAccessionedSequence:6784697] Creb3l3(1-?) [cytosol] [Mus musculus] [EntityWithAccessionedSequence:6784860] Creb3l3 [Golgi membrane] [Mus musculus] [EntityWithAccessionedSequence:6784868] Creb3l3(?-479) [Golgi membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q91XE9 Creb3l3 (225455)
