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Details on Person UniProt:P21964-2 COMT
| Class:Id | ReferenceIsoform:224929 |
|---|---|
| _chainChangeLog | chain:1-271 added on Sat February 7 2015 |
| _displayName | UniProt:P21964-2 COMT |
| _timestamp | 2026-02-20 21:38:26 |
| chain | chain:1-271 |
| checksum | D2547A1C399AC758 |
| comment | FUNCTION Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.CATALYTIC ACTIVITY a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY 2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY 4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY 2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)COFACTOR Binds 1 Mg(2+) ion per subunit.BIOPHYSICOCHEMICAL PROPERTIES kcats are 6.8 min(-1), 3.4 min(-1), 3.3 min(-1) and 6.7 min(-1) with 2-hydroxy-17beta-estradiol, 4-hydroxy-17beta-estradiol, 2-hydroxyestrone and 4-hydroxyestrone as substrates, respectively.INTERACTION Brain, liver, placenta, lymphocytes and erythrocytes.PTM The N-terminus is blocked.POLYMORPHISM Two major alleles, COMT*1 or COMT*H and COMT*2 or COMT*L are defined by a nucleotide G-to-A transition at codon 158, resulting in a valine-to-methionine substitution. Allele COMT*2 codes for protein variant p.Val158Met, a functional polymorphism resulting in 3- to 4-fold difference in catechol O-methyltransferase activity [MIM:621296].POLYMORPHISM Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIM:103780].DISEASE Disease susceptibility may be associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.ONLINE INFORMATION Catechol-O-methyl transferase entry |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="17"Catechol O-methyltransferase ecNumber evidence="6 8 13"2.1.1.6 |
| geneName | COMT |
| identifier | P21964 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative initiation Catecholamine metabolism Cell membrane Cytoplasm Direct protein sequencing Lipid metabolism Magnesium Membrane Metal-binding Methyltransferase Neurotransmitter degradation Phosphoprotein Proteomics identification Reference proteome S-adenosyl-L-methionine Schizophrenia Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | COMT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997648] ENSEMBL:ENSG00000093010 COMT [Homo sapiens] |
| secondaryIdentifier | COMT_HUMAN A8MPV9 Q6IB07 Q6ICE6 Q9BWC7 |
| sequenceLength | 271 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P21964-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P21964-2 COMT (224929)
