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Details on Person UniProt:Q96P44 COL21A1
Class:Id
ReferenceGeneProduct:224910
_chainChangeLog
signal peptide:1-22 added on Fri February 6 2015;chain:23-957 added on Fri February 6 2015
_displayName
UniProt:Q96P44 COL21A1
_timestamp
2024-08-09 19:19:59
chain
signal peptide:1-22 chain:23-957
checksum
4C5CDF5E6656A675
comment
SUBCELLULAR LOCATION Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle.ALTERNATIVE PRODUCTS Highly expressed in lymph node, jejunum, pancreas, stomach, trachea, testis, uterus and placenta; moderately expressed in brain, colon, lung, prostate, spinal cord, salivary gland and vascular smooth-muscle cells and very weakly expressed in heart, liver, kidney, bone marrow, spleen, thymus, skeletal muscle, adrenal gland and peripheral leukocytes. Expression in heart was higher in the right ventricle and atrium than in the left ventricle and atrium.DEVELOPMENTAL STAGE Highest expression observed at the fetal stage. Expressed by smooth-muscle cells in the artery wall in a PDGF-dependent way.INDUCTION Stimulated by PDGF/platelet-derived growth factor.SIMILARITY Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
